Measurement of imatinib plasma concentration can be useful to evaluate patient adherence to daily oral therapy, potential drug–drug interaction, treatment efficacy, and severe drug-related adverse events. The aim of this study was to correlate the two different blood level test methods, HPLC–UV and LC–MS/MS. We analyzed 162 plasma samples from patients treated with imatinib. We estimated the correlation between the two analytical methods on total data set and on five sets of patients grouped into different categories based on the drug-dose therapy. Finally, imatinib quantification was correlated with genetic data on the molecular response in monitoring follow-up of CML patients.

Quantification of imatinib plasma levels in patients with chronic myeloid leukemia: Comparison between HPLC-UV and LC-MS/MS

DE FRANCIA, SILVIA;PIRRO, Elisa;PICCIONE, Francesca;
2013

Abstract

Measurement of imatinib plasma concentration can be useful to evaluate patient adherence to daily oral therapy, potential drug–drug interaction, treatment efficacy, and severe drug-related adverse events. The aim of this study was to correlate the two different blood level test methods, HPLC–UV and LC–MS/MS. We analyzed 162 plasma samples from patients treated with imatinib. We estimated the correlation between the two analytical methods on total data set and on five sets of patients grouped into different categories based on the drug-dose therapy. Finally, imatinib quantification was correlated with genetic data on the molecular response in monitoring follow-up of CML patients.
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Drug monitoring; HPLC-UV; Imatinib plasma levels; LC-MS/MS; Biochemistry; Bioengineering; Molecular Medicine; Drug Discovery3003 Pharmaceutical Science; Analytical Chemistry
Caterino, Marianna; Casadei, Giada Muccioli; Arvonio, Raffaele; De Francia, Silvia; Pirro, Elisa; Piccione, Francesca Maria; Pane, Fabrizio; Ruoppolo, Margherita
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1533748
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