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NG2-expressingparenchymalprecursors(NG2+p)serveasprimarysourceofmyelinatingoligodendrocytesinboththedevelopingandadultCentralNervousSystem(CNS).However,theirabundance,limiteddifferentiationpotentialatadultstagesalongwithstereotypicreactiontoinjuryindependentoftheextentofmyelinlosssuggestthatNG+pexertfunctionsadditionaltomyelinproduction.Insupportofthisview,NG2+pexpressacomplexbatteryofmoleculesknowntoexertneuromodulatoryandneuroprotectivefunctions.Further,theyestablishintimatephysicalassociationswiththeotherCNScelltypes,receivefunctionalsynapticcontactsandpossessionchannelsapttoconstantlysensetheelectricalactivityofsurroundingneurons.TheselatterfeaturescouldendowNG2+pwiththecapabilitytoaffectneuronalfunctionswithpotentialhomeostaticoutcomes.HerewesummarizeanddiscusscurrentevidencefavoringtheviewthatNG2+pcanparticipateincircuitformation,modulateneuronalactivityandsurvivalinthehealthyandinjuredCNS,andproposeperspectivesforstudiesthatmaycompleteourunderstandingofNG2+prolesinphysiologyandpathology.

Beyond cell replacement: unresolved roles of NG2-expressing progenitors

BODA, Enrica;BUFFO, Annalisa
2014-01-01

Abstract

NG2-expressingparenchymalprecursors(NG2+p)serveasprimarysourceofmyelinatingoligodendrocytesinboththedevelopingandadultCentralNervousSystem(CNS).However,theirabundance,limiteddifferentiationpotentialatadultstagesalongwithstereotypicreactiontoinjuryindependentoftheextentofmyelinlosssuggestthatNG+pexertfunctionsadditionaltomyelinproduction.Insupportofthisview,NG2+pexpressacomplexbatteryofmoleculesknowntoexertneuromodulatoryandneuroprotectivefunctions.Further,theyestablishintimatephysicalassociationswiththeotherCNScelltypes,receivefunctionalsynapticcontactsandpossessionchannelsapttoconstantlysensetheelectricalactivityofsurroundingneurons.TheselatterfeaturescouldendowNG2+pwiththecapabilitytoaffectneuronalfunctionswithpotentialhomeostaticoutcomes.HerewesummarizeanddiscusscurrentevidencefavoringtheviewthatNG2+pcanparticipateincircuitformation,modulateneuronalactivityandsurvivalinthehealthyandinjuredCNS,andproposeperspectivesforstudiesthatmaycompleteourunderstandingofNG2+prolesinphysiologyandpathology.
2014
FRONTIERS IN NEUROSCIENCE
8
122
1
7
http://journal.frontiersin.org/article/10.3389/fnins.2014.00122/abstract
Enrica Boda;Annalisa Buffo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/154415
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