During fetal life, mesenchymal stromal/stem cells (MSCs) surround glomeruli and tubules and contribute to the development of the renal interstitium by secretion of growth factors that drive nephron differentiation. In the adult, an MSC-like population has been demonstrated in different compartments of human and murine nephrons. After injury, these cells might provide support for kidney regeneration by recapitulating the role they have in embryonic life. In this short review, we discuss the evidence of an MSC presence within the adult kidney and their potential contribution to the turnover of renal cells and injury repair.

Concise review: different mesenchymal stromal/stem cell populations reside in the adult kidney.

BRUNO, Stefania;CHIABOTTO, GIULIA;CAMUSSI, Giovanni
2014-01-01

Abstract

During fetal life, mesenchymal stromal/stem cells (MSCs) surround glomeruli and tubules and contribute to the development of the renal interstitium by secretion of growth factors that drive nephron differentiation. In the adult, an MSC-like population has been demonstrated in different compartments of human and murine nephrons. After injury, these cells might provide support for kidney regeneration by recapitulating the role they have in embryonic life. In this short review, we discuss the evidence of an MSC presence within the adult kidney and their potential contribution to the turnover of renal cells and injury repair.
2014
3
12
1451
1455
Mesenchymal stem cells; adult stem cells; renal stem cells; human glomeruli
Stefania Bruno; Giulia Chiabotto; Giovanni Camussi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/154668
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