Children receiving Total Body Irradiation (TBI) in preparation for Hematopoietic Stem Cell Transplantation (HSCT) are at risk for Growth Hormone Deficiency (GHD), which sometimes severely compromises their Final Height (FH). To better represent the impact of such therapies on growth we apply a mathematical model, which accounts both for the gompertzian-like growth trend and the hormone-related 'spurts', and evaluate how the parameter values estimated on the children undergoing TBI differ from those of the matched normal population.

Growth impairment after TBI of leukemia survivors children: a model-based investigation

GALLETTO, CHIARA MARIA;NUCERA, Daniele Michele;BERTORELLO, Nicoletta;BIASIN, Eleonora;FAGIOLI, FRANCA;GUIOT, Caterina
2014-01-01

Abstract

Children receiving Total Body Irradiation (TBI) in preparation for Hematopoietic Stem Cell Transplantation (HSCT) are at risk for Growth Hormone Deficiency (GHD), which sometimes severely compromises their Final Height (FH). To better represent the impact of such therapies on growth we apply a mathematical model, which accounts both for the gompertzian-like growth trend and the hormone-related 'spurts', and evaluate how the parameter values estimated on the children undergoing TBI differ from those of the matched normal population.
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Adolescent; Child; Female; Growth; Hematopoietic Stem Cell Transplantation; Humans; Infant; Leukemia; Male; Retrospective Studies; Transplantation Conditioning; Whole-Body Irradiation
Galletto, Chiara; Gliozzi, Antonio; Nucera, Daniele; Bertorello, Nicoletta; Biasin, Eleonora; Corrias, Andrea; Chiabotto, Patrizia; Fagioli, Franca; Guiot, Caterina
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1547838
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