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EnglishFMOC-isocyclosporine A, a fluorescent labeled cyclosporine A, was encapsulated in solid lipid nanoparticles (SLN) prepared by the coacervation technique, and its anti-inflammatory activity was evaluated. The anti-inflammatory activity of the fluorescent labelled molecule, measured as inhibition of TNF-α secretion, is similar to the native one. SLN were compared to commercial formulations, through measurement of cytokine release and drug uptake in rat peripheral blood mononuclear cells. Drug-loaded SLN inhibit TNF-α secretion in a lower extent than commercial formulations, probably due to a lower uptake by the cells, but the increase of IL-10 secretion caused by the lipid matrix itself makes this formulation interesting for its anti-inflammatory activity.
| Titolo: | Solid Lipid Nanoparticles Loaded with Fluorescent-labelled Cyclosporine A: Anti-inflammatory Activity in Vitro | |
| Autori Riconosciuti: | ||
| Autori: | Gallarate, M.; Serpe, L.; Foglietta, F.; Giordano, S.; Peira, E.; Chirio, D.; Battaglia, L. | |
| Data di pubblicazione: | 2014 | |
| Abstract: | FMOC-isocyclosporine A, a fluorescent labeled cyclosporine A, was encapsulated in solid lipid nanoparticles (SLN) prepared by the coacervation technique, and its anti-inflammatory activity was evaluated. The anti-inflammatory activity of the fluorescent labelled molecule, measured as inhibition of TNF-α secretion, is similar to the native one. SLN were compared to commercial formulations, through measurement of cytokine release and drug uptake in rat peripheral blood mononuclear cells. Drug-loaded SLN inhibit TNF-α secretion in a lower extent than commercial formulations, probably due to a lower uptake by the cells, but the increase of IL-10 secretion caused by the lipid matrix itself makes this formulation interesting for its anti-inflammatory activity. | |
| Volume: | 21 | |
| Fascicolo: | 11 | |
| Pagina iniziale: | 1157 | |
| Pagina finale: | 1162 | |
| Digital Object Identifier (DOI): | 10.2174/0929866521666140806164410 | |
| Parole Chiave: | Coacervation, cyclosporine A, cytokines, FMOC, inflammation, solid lipid nanoparticles. | |
| Rivista: | PROTEIN & PEPTIDE LETTERS | |
| Appare nelle tipologie: | 03A-Articolo su Rivista |
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| File | Descrizione | Tipologia | Licenza | |
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| Article revised_4aperto.pdf | POSTPRINT (VERSIONE FINALE DELL’AUTORE) | Accesso aperto | Open Access Visualizza/Apri | |
| articolo ciclosporina-fmoc.pdf | PDF EDITORIALE | Utenti riconosciuti Richiedi una copia |
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