AIMS: Granular cell astrocytomas (GCAs) are morphologically characterized by a prominent component of granular PAS-positive cells and show an increased aggressiveness compared to "ordinary" astrocytomas. Here, we studied in a small series of three GCAs the expression of mesenchymal/radioresistance-associated biomarkers (such as YKL-40, c-Met and Cav1), which could contribute to the poor outcome of this glioma subgroup. METHODS AND RESULTS: Our results show that GCAs, according to the new molecular glioma classifications, consistently display a prognostically negative molecular trait (IDH1wt-ATRX noloss-1p/19q nocodeletion). Furthermore, GCAs significantly differ from a control series of 33 "conventional" astrocytomas, because of a diffuse and strong immunohistochemical coexpression of YKL-40, c-Met and Cav1. CONCLUSIONS: Our findings show that specific morphological traits, such as a granular cell component, could represent useful features in guiding search for prognostic and predictive biomarkers, eventually amenable to targeted therapies (i.e. Met-inhibitors aimed at reducing radio-resistance). This article is protected by copyright. All rights reserved.

Mesenchymal/radioresistant traits in granular astrocytomas: Evidence from a combined clinical and molecular approach

SENETTA, REBECCA;CASTELLANO, ISABELLA;BERTERO, LUCA;SCHIFFER, Davide;CASSONI, Paola
Last
2016-01-01

Abstract

AIMS: Granular cell astrocytomas (GCAs) are morphologically characterized by a prominent component of granular PAS-positive cells and show an increased aggressiveness compared to "ordinary" astrocytomas. Here, we studied in a small series of three GCAs the expression of mesenchymal/radioresistance-associated biomarkers (such as YKL-40, c-Met and Cav1), which could contribute to the poor outcome of this glioma subgroup. METHODS AND RESULTS: Our results show that GCAs, according to the new molecular glioma classifications, consistently display a prognostically negative molecular trait (IDH1wt-ATRX noloss-1p/19q nocodeletion). Furthermore, GCAs significantly differ from a control series of 33 "conventional" astrocytomas, because of a diffuse and strong immunohistochemical coexpression of YKL-40, c-Met and Cav1. CONCLUSIONS: Our findings show that specific morphological traits, such as a granular cell component, could represent useful features in guiding search for prognostic and predictive biomarkers, eventually amenable to targeted therapies (i.e. Met-inhibitors aimed at reducing radio-resistance). This article is protected by copyright. All rights reserved.
2016
n/a
n/a
http://www3.interscience.wiley.com/journal/118511588/home
C-Met; Cav1; Granular-cell astrocytoma; Granular-cell glioblastoma; YKL-40; Histology; 2734
Senetta, Rebecca; Mellai, Marta; Manini, Claudia; Castellano, Isabella; Bertero, Luca; Pittaro, Alessandra; Schiffer, Davide; Boldorini, Renzo; Casson...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1561916
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