No standard chemotherapy is available for anaplastic thyroid cancer (ATC). Drug-loaded nanobubbles (NBs) are a promising innovative anticancer drug formulation, and combining them with an externally applied trigger may further control drug release at the target region. Extracorporeal shock waves (ESWs) are acoustic waves widely used in urology and orthopedics, with no side effects. The aim of the present work was to combine ESWs and new doxorubicin-loaded glycol chitosan NBs in order to target doxorubicin and enhance its antitumor effect in ATC cell lines.
Doxorubicin-Loaded Nanobubbles Combined with Extracorporeal Shock Waves: Basis for a New Drug Delivery Tool in Anaplastic Thyroid Cancer
MARANO, FRANCESCA;ARGENZIANO, MONICA
Co-first
;FRAIRIA, Roberto;BOSCO, Ornella;RINELLA, LETIZIA;CAVALLI, Roberta;CATALANO, Maria Graziella
2016-01-01
Abstract
No standard chemotherapy is available for anaplastic thyroid cancer (ATC). Drug-loaded nanobubbles (NBs) are a promising innovative anticancer drug formulation, and combining them with an externally applied trigger may further control drug release at the target region. Extracorporeal shock waves (ESWs) are acoustic waves widely used in urology and orthopedics, with no side effects. The aim of the present work was to combine ESWs and new doxorubicin-loaded glycol chitosan NBs in order to target doxorubicin and enhance its antitumor effect in ATC cell lines.
File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
Marano et al. Aperto_4aperto.pdf
Open Access dal 01/01/2018
Tipo di file:
POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione
918.49 kB
Formato
Adobe PDF
|
918.49 kB | Adobe PDF | Visualizza/Apri |
|
Marano et al. 2016.pdf
Accesso riservato
Tipo di file:
PDF EDITORIALE
Dimensione
803.68 kB
Formato
Adobe PDF
|
803.68 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
