Patient-specific (unique) tumour antigens, encoded by somatically mutated cancer genes, generate neoepitopes that are implicated in the induction of tumour-controlling T cell responses. Recent advancements in massive DNA sequencing combined with robust T cell epitope predictions have allowed their systematic identification in several malignancies.

T cell neoepitope discovery in colorectal cancer by high throughput profiling of somatic mutations in expressed genes

AMOROSO, Antonio;
2017

Abstract

Patient-specific (unique) tumour antigens, encoded by somatically mutated cancer genes, generate neoepitopes that are implicated in the induction of tumour-controlling T cell responses. Recent advancements in massive DNA sequencing combined with robust T cell epitope predictions have allowed their systematic identification in several malignancies.
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534766/
ANTIGENS; CANCER IMMUNOBIOLOGY; COLORECTAL CANCER; GENE MUTATION; IMMUNE RESPONSE
Mennonna, Daniele; Maccalli, Cristina; Romano, Michele C; Garavaglia, Claudio; Capocefalo, Filippo; Bordoni, Roberta; Severgnini, Marco; De Bellis, Gianluca; Sidney, John; Sette, Alessandro; Gori, Alessandro; Longhi, Renato; Braga, Marco; Ghirardelli, Luca; Baldari, Ludovica; Orsenigo, Elena; Albarello, Luca; Zino, Elisabetta; Fleischhauer, Katharina; Mazzola, Gina; Ferrero, Norma; Amoroso, Antonio; Casorati, Giulia; Parmiani, Giorgio; Dellabona, Paolo
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1568874
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