The development of green protocols for amide bond formation is a major socioeconomic goal for chemical and pharmaceutical industries and an important challenge for academic research. We herein report a protocol for the quantitative conversion of carboxylic acids and amines to form amides at 100°C in the presence of a TiO2 powder catalyst, under monomodal microwave irradiation. The sustainability of the process appears to be augmented by the ease with which the catalyst is recycled.
Fast TiO2-catalyzed direct Amidation of Carboxylic Acids under mild dielectric Heating
CALCIO GAUDINO, Emanuela;CARNAROGLIO, DIEGO;MARTRA, Gianmario;CRAVOTTO, Giancarlo
2014-01-01
Abstract
The development of green protocols for amide bond formation is a major socioeconomic goal for chemical and pharmaceutical industries and an important challenge for academic research. We herein report a protocol for the quantitative conversion of carboxylic acids and amines to form amides at 100°C in the presence of a TiO2 powder catalyst, under monomodal microwave irradiation. The sustainability of the process appears to be augmented by the ease with which the catalyst is recycled.
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Calcio Gaudino - MOD_4aperto.pdf
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