Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors. Functional studies demonstrated that this kinase-activating alteration likely constitutes a driver of PLGA.

Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands

MARCHIO', Caterina;
2014-01-01

Abstract

Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors. Functional studies demonstrated that this kinase-activating alteration likely constitutes a driver of PLGA.
2014
46
11
1166
1169
http://www.nature.com/ng/journal/v46/n11/full/ng.3096.html
PRKD1; salivary glands; Polymorphous low-grade adenocarcinoma
Ilan Weinreb;Salvatore Piscuoglio;Luciano G Martelotto;Daryl Waggott;Charlotte K Y Ng;Bayardo Perez-Ordonez;Nicholas J Harding;Javier Alfaro;Kenneth C Chu;Agnes Viale;Nicola Fusco;Arnaud da Cruz Paula;Caterina Marchio;Rita A Sakr;Raymond Lim;Lester D R Thompson;Simion I Chiosea;Raja R Seethala;Alena Skalova;Edward B Stelow;Isabel Fonseca;Adel Assaad;Christine How;Jianxin Wang;Richard de Borja;Michelle Chan-Seng-Yue;Christopher J Howlett;Anthony C Nichols;Y Hannah Wen;Nora Katabi;Nicholas Buchner;Laura Mullen;Thomas Kislinger;Bradly G Wouters;Fei-Fei Liu;Larry Norton;John D McPherson;Brian P Rubin;Blaise A Clarke;Britta Weigelt;Paul C Boutros;Jorge S Reis-Filho
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/157489
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