Cyclopamine- and paclitaxel-containing hetero-nanoparticles generated by self-assembly show combined efficacy in the treatment of three different cancer cell lines. The use of ternary combination with the addition of a dye-squalene conjugate secured the obtainment of fluorescent nanoparticles that permitted the observation of the cellular internalization by confocal microscopy and super-resolution dSTORM (direct stochastic optical reconstruction microscopy).

Cyclopamine-paclitaxel-containing nanoparticles: internalization in cells detected by confocal and super-resolution microscopy

STELLA, Barbara;DOSIO, Franco;
2015

Abstract

Cyclopamine- and paclitaxel-containing hetero-nanoparticles generated by self-assembly show combined efficacy in the treatment of three different cancer cell lines. The use of ternary combination with the addition of a dye-squalene conjugate secured the obtainment of fluorescent nanoparticles that permitted the observation of the cellular internalization by confocal microscopy and super-resolution dSTORM (direct stochastic optical reconstruction microscopy).
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Cancer stem cells, cyclopamine, nanoparticles, paclitaxel
Fumagalli, G.; Mazza, D.; Christodoulou, M.S.; Damia, G.; Ricci, F.; Perdicchia, D.; Stella, B.; Dosio, F.; Sotiropoulou, P.A.; Passarella, D.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1577845
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