Obesity increases the risk of endometrial and ovarian cancer, and oestrogen receptor (ER)-progesterone receptor (PR)-positive postmenopausal breast cancer. A modest positive association between body mass index (BMI) and cervical cancer has also been found. By contrast, an inverse correlation between BMI and premenopausal breast cancer exists. Endogenous sex hormones, insulin resistance/hyperinsulinaemia, adipokines, cytokines and chronic inflammation, among other factors, may be involved in the promotion of cancer in obese patients. Obesity is also associated with an increased risk of cancer recurrence and mortality most likely due to suboptimal treatment and/or co-morbidities. It is recommended that chemotherapy doses be calculated on the actual body weight and that radical surgery be performed as in non-obese patients. The high risk of peri-operative complications may be reduced by optimizing preoperative clinical conditions. As part of cancer prevention, obese women should be encouraged to adopt healthy lifestyles leading to weight loss and to undergo regular cancer screening.

Obesity and female malignancies

BENEDETTO, Chiara
First
;
SALVAGNO, Francesca;CANUTO, Emilie Marion;
2015

Abstract

Obesity increases the risk of endometrial and ovarian cancer, and oestrogen receptor (ER)-progesterone receptor (PR)-positive postmenopausal breast cancer. A modest positive association between body mass index (BMI) and cervical cancer has also been found. By contrast, an inverse correlation between BMI and premenopausal breast cancer exists. Endogenous sex hormones, insulin resistance/hyperinsulinaemia, adipokines, cytokines and chronic inflammation, among other factors, may be involved in the promotion of cancer in obese patients. Obesity is also associated with an increased risk of cancer recurrence and mortality most likely due to suboptimal treatment and/or co-morbidities. It is recommended that chemotherapy doses be calculated on the actual body weight and that radical surgery be performed as in non-obese patients. The high risk of peri-operative complications may be reduced by optimizing preoperative clinical conditions. As part of cancer prevention, obese women should be encouraged to adopt healthy lifestyles leading to weight loss and to undergo regular cancer screening.
29
4
528
540
http://www.elsevier.com/inca/publications/store/6/2/3/0/0/4/index.htt
breast cancer; cervical cancer; endometrial cancer; obesity; ovarian cancer; treatment; Breast Neoplasms; Endometrial Neoplasms; Estrogens; Female; Genital Neoplasms, Female; Humans; Neoplasms, Hormone-Dependent; Obesity; Ovarian Neoplasms; Receptors, Estrogen; Uterine Cervical Neoplasms; Obstetrics and Gynecology; Medicine (all)
Benedetto, Chiara; Salvagno, Francesca; Canuto, Emilie Marion; Gennarelli, Gianluca
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S1521693415000164-main.pdf

Accesso riservato

Tipo di file: PDF EDITORIALE
Dimensione 315.07 kB
Formato Adobe PDF
315.07 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1578158
Citazioni
  • ???jsp.display-item.citation.pmc??? 14
  • Scopus 33
  • ???jsp.display-item.citation.isi??? 25
social impact