The ADP-ribosyl cyclases are unique enzymes that catalyse the cyclization of NAD/NADP to cyclic ADP ribose NAADP, two widely distributed second messengers involved in intracellular calcium mobilization and signalling. This review will focus on the group of well-characterized invertebrate and vertebrate ARCs whose common gene structure allows us to trace their origin to the ancestor of bilaterian animals. Behind a facade of gene and protein homology lies a family with a disparate functional repertoire dictated by the animal model and the physical trait under investigation. Here we present a phylogenetic view of the ARCs to better understand the evolution of function in this family.

The ADP-ribosyl cyclases - the current evolutionary state of the ARCs

FERRERO, Enza;LO BUONO, NICOLA;HORENSTEIN, ALBERTO;FUNARO, Ada;MALAVASI, Fabio
2014

Abstract

The ADP-ribosyl cyclases are unique enzymes that catalyse the cyclization of NAD/NADP to cyclic ADP ribose NAADP, two widely distributed second messengers involved in intracellular calcium mobilization and signalling. This review will focus on the group of well-characterized invertebrate and vertebrate ARCs whose common gene structure allows us to trace their origin to the ancestor of bilaterian animals. Behind a facade of gene and protein homology lies a family with a disparate functional repertoire dictated by the animal model and the physical trait under investigation. Here we present a phylogenetic view of the ARCs to better understand the evolution of function in this family.
19
986
1002
evolution; gene family; ADP-ribosyl cyclase
Ferrero E; Lo Buono N; Horenstein AL; Funaro A; Malavasi F.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/157979
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