DNA methylation is one of the most studied epigenetic modifications and is essential for mammalian development. The methylation pattern is established through an extremely orchestrated mechanism that implicates de novo methylation, maintenance of the methylated cytosine, and demethylation. DNA methylation is catalyzed by the well-characterized DNA methyltransferase family enzymes (DNMTs), including the DNMT3A and DNMT3B that are responsible for the de novo methylation and DNMT1 that is the mediator of the maintenance of the DNA methylation pattern through cell replication
DNA methylation and demethylation dynamics
Neri, Francesco;INCARNATO, DANNY;OLIVIERO, Salvatore
Last
2015-01-01
Abstract
DNA methylation is one of the most studied epigenetic modifications and is essential for mammalian development. The methylation pattern is established through an extremely orchestrated mechanism that implicates de novo methylation, maintenance of the methylated cytosine, and demethylation. DNA methylation is catalyzed by the well-characterized DNA methyltransferase family enzymes (DNMTs), including the DNMT3A and DNMT3B that are responsible for the de novo methylation and DNMT1 that is the mediator of the maintenance of the DNA methylation pattern through cell replication
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