Growing evidence suggests that small vesicles actively released from cells may encapsulate transcriptional regulators and RNA molecules. Their ability to interact with neighbouring cells and/or with distant cells through biological fluids, makes them a medium through which intercellular exchange of information can happen. Recently, membrane vesicles, which include exosomes and microvesicles, gained a place amongst the vast group of angiogenic mediators. In the present review we discuss the potential relevance of these vesicles in physiological and pathological situations of angiogenesis as well as their mechanism of action.

Extracellular vesicles as new players in angiogenesis.

RANGHINO, Andrea;LOPATINA, Tatiana;DEREGIBUS, Maria Chiara;RISPOLI, Pietro;BRIZZI, Maria Felice;CAMUSSI, Giovanni
2016-01-01

Abstract

Growing evidence suggests that small vesicles actively released from cells may encapsulate transcriptional regulators and RNA molecules. Their ability to interact with neighbouring cells and/or with distant cells through biological fluids, makes them a medium through which intercellular exchange of information can happen. Recently, membrane vesicles, which include exosomes and microvesicles, gained a place amongst the vast group of angiogenic mediators. In the present review we discuss the potential relevance of these vesicles in physiological and pathological situations of angiogenesis as well as their mechanism of action.
2016
1
7
Angiogenesis; Exosomes; Microvesicles; miRNAs
Kholia, S; Ranghino, Andrea; Garnieri, P; Lopatina, Tatiana; Deregibus, Maria Chiara; Rispoli, Pietro; Brizzi, Maria Felice; Camussi, Giovanni
File in questo prodotto:
File Dimensione Formato  
Brizzi_Extracellular vesicles as new players in angiogenesis.pdf

Accesso aperto

Tipo di file: POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione 443.68 kB
Formato Adobe PDF
443.68 kB Adobe PDF Visualizza/Apri
1-s2.0-S1537189115301051-main-1.pdf

Accesso riservato

Tipo di file: PDF EDITORIALE
Dimensione 961.99 kB
Formato Adobe PDF
961.99 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1593094
Citazioni
  • ???jsp.display-item.citation.pmc??? 38
  • Scopus 71
  • ???jsp.display-item.citation.isi??? 59
social impact