Over the past few years, there have been considerable advances in the treatments available to patients with metastatic or locally advanced non-small cell lung cancer (NSCLC), particularly those who have progressed on or during first-line treatment. Some of the treatment options available to patients are discussed here, with a focus on checkpoint inhibitor immunotherapies (nivolumab and pembrolizumab) and antiangiogenic agents (bevacizumab, ramucirumab and nintedanib). It is hypothesised that combining immunotherapy with antiangiogenic treatment may have a synergistic effect and enhance the efficacy of both treatments. In this review, we explore the theory and potential of this novel treatment option for patients with advanced NSCLC. We discuss the growing body of evidence that pro-angiogenic factors can modulate the immune response (both by reducing T-cell infiltration into the tumour microenvironment, and through systemic effects on immune-regulatory cell function) and examine the preclinical evidence for combining these treatments. Potential challenges are also considered, and we review the preliminary evidence of clinical efficacy and safety with this novel combination in a variety of solid tumour types.

The potential of combined immunotherapy and antiangiogenesis for the synergistic treatment of advanced NSCLC.

NOVELLO, Silvia;PAPOTTI, Mauro Giulio;
2017-01-01

Abstract

Over the past few years, there have been considerable advances in the treatments available to patients with metastatic or locally advanced non-small cell lung cancer (NSCLC), particularly those who have progressed on or during first-line treatment. Some of the treatment options available to patients are discussed here, with a focus on checkpoint inhibitor immunotherapies (nivolumab and pembrolizumab) and antiangiogenic agents (bevacizumab, ramucirumab and nintedanib). It is hypothesised that combining immunotherapy with antiangiogenic treatment may have a synergistic effect and enhance the efficacy of both treatments. In this review, we explore the theory and potential of this novel treatment option for patients with advanced NSCLC. We discuss the growing body of evidence that pro-angiogenic factors can modulate the immune response (both by reducing T-cell infiltration into the tumour microenvironment, and through systemic effects on immune-regulatory cell function) and examine the preclinical evidence for combining these treatments. Potential challenges are also considered, and we review the preliminary evidence of clinical efficacy and safety with this novel combination in a variety of solid tumour types.
2017
12
2
194
207
https://www.ncbi.nlm.nih.gov/pubmed/27729297
http://www.sciencedirect.com/science/article/pii/S155608641631142X
Manegold, C; Dingemans, Ac; Gray, Je; Nakagawa, K; Nicolson, M; Peters, S; Reck, M; Wu, Yl; Brustugun, Ot; Crino, L; Felip, E; Fennell, D; Garrido, P; Huber, Rm; Marabelle, A; Moniuszko, M; Mornex, F; Novello, S; Papotti, M; Pérol, M; Smit, Ef; Syrigos, K; van Meerbeeck, Jp; van Zandwijk, N; Chih-Hsin Yang, J; Zhou, C; Vokes, E.
File in questo prodotto:
File Dimensione Formato  
The potential of combined immunotherapy and antiangiogenesis for the synergistic treatment of advanced NSCLC - pprint.docx

Accesso riservato

Tipo di file: POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione 322.2 kB
Formato Microsoft Word XML
322.2 kB Microsoft Word XML   Visualizza/Apri   Richiedi una copia
The potential of combined immunotherapy-pprint.pdf

Accesso aperto

Tipo di file: POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione 370.61 kB
Formato Adobe PDF
370.61 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1601869
Citazioni
  • ???jsp.display-item.citation.pmc??? 100
  • Scopus 184
  • ???jsp.display-item.citation.isi??? 168
social impact