Although eye drops are widely used as drug delivery systems for the anterior segment of the eye, they are also associated with poor drug bioavailability due to transient contact time and rapid washout by tearing. Moreover, effective drug delivery to the posterior segment of the eye is challenging, and alternative routes of administration (periocular and intravitreal) are generally needed, the blood-retinal barrier being the major obstacle to systemic drug delivery.
Application of lipid nanoparticles to ocular drug delivery
BATTAGLIA, Luigi Sebastiano
First
;SERPE, Loredana;FOGLIETTA, FEDERICA;MUNTONI, Elisabetta;GALLARATE, Marina;
2016-01-01
Abstract
Although eye drops are widely used as drug delivery systems for the anterior segment of the eye, they are also associated with poor drug bioavailability due to transient contact time and rapid washout by tearing. Moreover, effective drug delivery to the posterior segment of the eye is challenging, and alternative routes of administration (periocular and intravitreal) are generally needed, the blood-retinal barrier being the major obstacle to systemic drug delivery.
File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
review oculare.pdf
Open Access dal 02/06/2017
Tipo di file:
POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione
800.03 kB
Formato
Adobe PDF
|
800.03 kB | Adobe PDF | Visualizza/Apri |
|
review oculare 2.pdf
Accesso riservato
Tipo di file:
PDF EDITORIALE
Dimensione
2.19 MB
Formato
Adobe PDF
|
2.19 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
