Although eye drops are widely used as drug delivery systems for the anterior segment of the eye, they are also associated with poor drug bioavailability due to transient contact time and rapid washout by tearing. Moreover, effective drug delivery to the posterior segment of the eye is challenging, and alternative routes of administration (periocular and intravitreal) are generally needed, the blood-retinal barrier being the major obstacle to systemic drug delivery.

Application of lipid nanoparticles to ocular drug delivery

BATTAGLIA, Luigi Sebastiano
First
;
SERPE, Loredana;FOGLIETTA, FEDERICA;MUNTONI, Elisabetta;GALLARATE, Marina;
2016

Abstract

Although eye drops are widely used as drug delivery systems for the anterior segment of the eye, they are also associated with poor drug bioavailability due to transient contact time and rapid washout by tearing. Moreover, effective drug delivery to the posterior segment of the eye is challenging, and alternative routes of administration (periocular and intravitreal) are generally needed, the blood-retinal barrier being the major obstacle to systemic drug delivery.
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Solid lipid nanoparticles; drug delivery; eye; nanostructured lipid carrier
Battaglia, Luigi; Serpe, Loredana; Foglietta, Federica; Muntoni, Elisabetta; Gallarate, Marina; Del Pozo Rodriguez, Ana; Solinis, Maria Angeles
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1609995
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