Thymidylate synthase (TS), one of the key enzymes for thymidine synthesis, is a target of pemetrexed (PEM), a key agent for the systemic therapy of malignant pleural mesothelioma (MPM) and its overexpression has been correlated to PEM-resistance. In MPM, experimental data report activation of the c-SRC tyrosine kinase suggesting it as a potential target to be further investigated.

Dasatinib modulates sensitivity to pemetrexed in malignant pleural mesothelioma cell lines

MONICA, Valentina;LO IACONO, MARCO;BRACCO, Enrico;BUSSO, SIMONE;DI BLASIO, LAURA;PRIMO, Luca;PERACINO, Barbara;PAPOTTI, Mauro Giulio;SCAGLIOTTI, Giorgio Vittorio
Last
2016

Abstract

Thymidylate synthase (TS), one of the key enzymes for thymidine synthesis, is a target of pemetrexed (PEM), a key agent for the systemic therapy of malignant pleural mesothelioma (MPM) and its overexpression has been correlated to PEM-resistance. In MPM, experimental data report activation of the c-SRC tyrosine kinase suggesting it as a potential target to be further investigated.
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cell lines; dasatinib; malignant pleural mesothelioma; pemetrexed; thymidylate synthase
Monica, Valentina; Lo Iacono, Marco; Bracco, Enrico; Busso, Simone; Di Blasio, Laura; Primo, Luca; Peracino, Barbara; Papotti, Mauro; Scagliotti, Giorgio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1610357
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