Thymidylate synthase (TS), one of the key enzymes for thymidine synthesis, is a target of pemetrexed (PEM), a key agent for the systemic therapy of malignant pleural mesothelioma (MPM) and its overexpression has been correlated to PEM-resistance. In MPM, experimental data report activation of the c-SRC tyrosine kinase suggesting it as a potential target to be further investigated.
Dasatinib modulates sensitivity to pemetrexed in malignant pleural mesothelioma cell lines
MONICA, Valentina;LO IACONO, MARCO;BRACCO, Enrico;BUSSO, SIMONE;DI BLASIO, LAURA;PRIMO, Luca;PERACINO, Barbara;PAPOTTI, Mauro Giulio;SCAGLIOTTI, Giorgio Vittorio
Last
2016-01-01
Abstract
Thymidylate synthase (TS), one of the key enzymes for thymidine synthesis, is a target of pemetrexed (PEM), a key agent for the systemic therapy of malignant pleural mesothelioma (MPM) and its overexpression has been correlated to PEM-resistance. In MPM, experimental data report activation of the c-SRC tyrosine kinase suggesting it as a potential target to be further investigated.
File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
Monica V, OT 2016.pdf
Accesso aperto
Descrizione: Articolo completo
Tipo di file:
PDF EDITORIALE
Dimensione
5.98 MB
Formato
Adobe PDF
|
5.98 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
