In the last 20 years, following the identification of the BRCA1 and BRCA2 genes (hereinafter referred to as the BRCA genes), preventive pathways have been developed for the identification and clinical management of individuals at high risk of developing breast and ovarian cancer due to the presence of a pathogenic variant in either of these genes. These pathways are aimed at educating high-risk subjects on programs targeted toward early diagnosis and cancer risk reduction.

Recommendations for the implementation of BRCA testing in the care and treatment pathways of ovarian cancer patients.

GENUARDI, Maurizio;MARCHETTI, PAOLO;NORMANNO, Nicola;PASINI, Barbara;RUSSO, Antonio Fabio;
2016

Abstract

In the last 20 years, following the identification of the BRCA1 and BRCA2 genes (hereinafter referred to as the BRCA genes), preventive pathways have been developed for the identification and clinical management of individuals at high risk of developing breast and ovarian cancer due to the presence of a pathogenic variant in either of these genes. These pathways are aimed at educating high-risk subjects on programs targeted toward early diagnosis and cancer risk reduction.
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http://www.futuremedicine.com/doi/abs/10.2217/fon-2016-0189
BRCA1, BRCA2, genetic testing, germline mutations, somatic mutations, ovarian cancer, PARP inibitors
Pinto, Carmine; Bell, Maria Angela; Capoluongo, Ettore; Carrera, Paola; Clemente, Claudio; Colombo, Nicoletta; Cortesi, Laura; Rosa, Gaetano De; Fenizia, Francesca; Genuardi, Maurizio; Gori, Stefania; Guarneri, Valentina; Marchetti, Antonio; Marchetti, Paolo; Normanno, Nicola; Pasini, Barbara; Pignata, Sandro; Radice, Paolo; Ricevuto, Enrico; Russo, Antonio; Tagliaferri, Pierosandro; Tassone, Pierfrancesco; Truini, Mauro; Varesco, Liliana .
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1613972
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