Deferasirox adverse effects include the following: gastrointestinal disturbance, mild elevations in serum creatinine levels and intermittent proteinuria; these events are dose-dependent and reversible with drug discontinuation, but this solution can lead to an inadequate iron chelation. For these reasons, interindividual variability of drug plasma concentration could help the clinical management of deferasirox dosage. We sought to describe deferasirox plasma exposure in a cohort of 60 adult patients.

Deferasirox pharmacokinetic and toxicity correlation in β-thalassaemia major treatment

ALLEGRA, SARAH;DE FRANCIA, SILVIA;CUSATO, JESSICA;PIRRO, Elisa;MASSANO, DAVIDE;PIGA, Antonio Giulio;D'AVOLIO, ANTONIO
Last
2016

Abstract

Deferasirox adverse effects include the following: gastrointestinal disturbance, mild elevations in serum creatinine levels and intermittent proteinuria; these events are dose-dependent and reversible with drug discontinuation, but this solution can lead to an inadequate iron chelation. For these reasons, interindividual variability of drug plasma concentration could help the clinical management of deferasirox dosage. We sought to describe deferasirox plasma exposure in a cohort of 60 adult patients.
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Exjade®; iron chelation; iron overload; thalassaemia; therapeutic drug monitoring
Allegra, Sarah; De Francia, Silvia; Cusato, Jessica; Pirro, Elisa; Massano, Davide; Piga, Antonio; D'Avolio, Antonio
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1615142
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