Sleep-wake disturbances are often reported in Prader-Willi syndrome (PWS), a rare neurodevelopmental syndrome that is associated with paternally-expressed genomic imprinting defects within the human chromosome region 15q11-13. One of the candidate genes, prevalently expressed in the brain, is the small nucleolar ribonucleic acid-116 (SNORD116). Here we conducted a translational study into the sleep abnormalities of PWS, testing the hypothesis that SNORD116 is responsible for sleep defects that characterize the syndrome.

Deletion of the Snord116/SNORD116 Alters Sleep in Mice and Patients with Prader-Willi Syndrome.

PRIANO, LORENZO;MAURO, Alessandro;
2016-01-01

Abstract

Sleep-wake disturbances are often reported in Prader-Willi syndrome (PWS), a rare neurodevelopmental syndrome that is associated with paternally-expressed genomic imprinting defects within the human chromosome region 15q11-13. One of the candidate genes, prevalently expressed in the brain, is the small nucleolar ribonucleic acid-116 (SNORD116). Here we conducted a translational study into the sleep abnormalities of PWS, testing the hypothesis that SNORD116 is responsible for sleep defects that characterize the syndrome.
2016
39
3
637
644
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763347/
Prader-Willi; Snord116; sleep; temperature; theta rhythms
Lassi, Glenda; Priano, Lorenzo; Maggi, Silvia; Garcia Garcia, Celina; Balzani, Edoardo; El Assawy, Nadia; Pagani, Marco; Tinarelli, Federico; Giardino...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1616703
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