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EnglishAngiogenesis is one of the hallmarks of cancer, including brain tumors. Malignant gliomas have the highest degree of vascular proliferation among solid tumors; thus, angiogenic pathways represent an attractive target to interfere with tumor growth. Up to date VEGF pathway targeting with specific drugs has yielded interesting therapeutics results. In particular bevacizumab, a monoclonal antibody against VEGF-A, has shown clinical activity in malignant gliomas, especially glioblastomas, in terms of a high response rate on MRI and a significant increase in progression-free survival.
| Titolo: | Antiangiogenic therapy of brain tumors: The role of bevacizumab |
| Autori Riconosciuti: | |
| Autori: | Trevisan, Elisa; Bertero, Luca; Bosa, Chiara; Magistrello, Michela; Pellerino, Alessia; Rudà, Roberta; Soffietti, Riccardo |
| Data di pubblicazione: | 2014 |
| Abstract: | Angiogenesis is one of the hallmarks of cancer, including brain tumors. Malignant gliomas have the highest degree of vascular proliferation among solid tumors; thus, angiogenic pathways represent an attractive target to interfere with tumor growth. Up to date VEGF pathway targeting with specific drugs has yielded interesting therapeutics results. In particular bevacizumab, a monoclonal antibody against VEGF-A, has shown clinical activity in malignant gliomas, especially glioblastomas, in terms of a high response rate on MRI and a significant increase in progression-free survival. |
| Volume: | 35 |
| Fascicolo: | 4 |
| Pagina iniziale: | 507 |
| Pagina finale: | 514 |
| Digital Object Identifier (DOI): | 10.1007/s10072-014-1627-6 |
| URL: | link.springer.de/link/service/journals/10072/index.htm |
| Parole Chiave: | Angiogenesis; Bevacizumab; Glioblastoma; High-grade glioma; VEGF; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Bevacizumab; Brain; Brain Neoplasms; Glioblastoma; Humans; Vascular Endothelial Growth Factors; Neurology (clinical); Psychiatry and Mental Health; 2708 |
| Rivista: | NEUROLOGICAL SCIENCES |
| Appare nelle tipologie: | 03B-Review in Rivista / Rassegna della Lett. in Riv. / Nota Critica |
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