Angiogenesis is one of the hallmarks of cancer, including brain tumors. Malignant gliomas have the highest degree of vascular proliferation among solid tumors; thus, angiogenic pathways represent an attractive target to interfere with tumor growth. Up to date VEGF pathway targeting with specific drugs has yielded interesting therapeutics results. In particular bevacizumab, a monoclonal antibody against VEGF-A, has shown clinical activity in malignant gliomas, especially glioblastomas, in terms of a high response rate on MRI and a significant increase in progression-free survival.

Antiangiogenic therapy of brain tumors: The role of bevacizumab

TREVISAN, Elisa;BERTERO, LUCA;MAGISTRELLO, MICHELA;PELLERINO, Alessia;Rudà, Roberta;SOFFIETTI, Riccardo
2014-01-01

Abstract

Angiogenesis is one of the hallmarks of cancer, including brain tumors. Malignant gliomas have the highest degree of vascular proliferation among solid tumors; thus, angiogenic pathways represent an attractive target to interfere with tumor growth. Up to date VEGF pathway targeting with specific drugs has yielded interesting therapeutics results. In particular bevacizumab, a monoclonal antibody against VEGF-A, has shown clinical activity in malignant gliomas, especially glioblastomas, in terms of a high response rate on MRI and a significant increase in progression-free survival.
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link.springer.de/link/service/journals/10072/index.htm
Angiogenesis; Bevacizumab; Glioblastoma; High-grade glioma; VEGF; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Bevacizumab; Brain; Brain Neoplasms; Glioblastoma; Humans; Vascular Endothelial Growth Factors; Neurology (clinical); Psychiatry and Mental Health; 2708
Trevisan, Elisa; Bertero, Luca; Bosa, Chiara; Magistrello, Michela; Pellerino, Alessia; Rudà, Roberta; Soffietti, Riccardo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1617163
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