CINECA IRIS Institutional Research Information System
IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Torino.
AperTO è l'archivio istituzionale Open Access destinato a raccogliere, rendere visibile e conservare la produzione scientifica dell'Università degli Studi di Torino.
EnglishAngiogenesis is one of the hallmarks of cancer, including brain tumors. Malignant gliomas have the highest degree of vascular proliferation among solid tumors; thus, angiogenic pathways represent an attractive target to interfere with tumor growth. Up to date VEGF pathway targeting with specific drugs has yielded interesting therapeutics results. In particular bevacizumab, a monoclonal antibody against VEGF-A, has shown clinical activity in malignant gliomas, especially glioblastomas, in terms of a high response rate on MRI and a significant increase in progression-free survival.
| Titolo: | Antiangiogenic therapy of brain tumors: The role of bevacizumab |
| Autori Riconosciuti: | |
| Autori: | Trevisan, Elisa; Bertero, Luca; Bosa, Chiara; Magistrello, Michela; Pellerino, Alessia; Rudà, Roberta; Soffietti, Riccardo |
| Data di pubblicazione: | 2014 |
| Abstract: | Angiogenesis is one of the hallmarks of cancer, including brain tumors. Malignant gliomas have the highest degree of vascular proliferation among solid tumors; thus, angiogenic pathways represent an attractive target to interfere with tumor growth. Up to date VEGF pathway targeting with specific drugs has yielded interesting therapeutics results. In particular bevacizumab, a monoclonal antibody against VEGF-A, has shown clinical activity in malignant gliomas, especially glioblastomas, in terms of a high response rate on MRI and a significant increase in progression-free survival. |
| Volume: | 35 |
| Fascicolo: | 4 |
| Pagina iniziale: | 507 |
| Pagina finale: | 514 |
| Digital Object Identifier (DOI): | 10.1007/s10072-014-1627-6 |
| URL: | link.springer.de/link/service/journals/10072/index.htm |
| Parole Chiave: | Angiogenesis; Bevacizumab; Glioblastoma; High-grade glioma; VEGF; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Bevacizumab; Brain; Brain Neoplasms; Glioblastoma; Humans; Vascular Endothelial Growth Factors; Neurology (clinical); Psychiatry and Mental Health; 2708 |
| Rivista: | NEUROLOGICAL SCIENCES |
| Appare nelle tipologie: | 03B-Review in Rivista / Rassegna della Lett. in Riv. / Nota Critica |
File in questo prodotto:
Copyright © 2021