Antiretroviral treatment is highly effective in enhancing HIV-positive patients' survival and quality of life. Despite an increased tolerability in recent years, a substantial amount of patients experience side effects. Antiretrovirals' efficacy and tolerability have been associated with plasma concentrations and single nucleotide polymorphisms in selected genes involved in drug disposition.
Genetic Polymorphisms Affecting the Pharmacokinetics of Antiretroviral Drugs
CALCAGNO, Andrea
First
;CUSATO, JESSICA;D'AVOLIO, ANTONIO;BONORA, Stefano
Last
2017-01-01
Abstract
Antiretroviral treatment is highly effective in enhancing HIV-positive patients' survival and quality of life. Despite an increased tolerability in recent years, a substantial amount of patients experience side effects. Antiretrovirals' efficacy and tolerability have been associated with plasma concentrations and single nucleotide polymorphisms in selected genes involved in drug disposition.
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