Context: Von Hippel–Lindau disease (VHLD) is a rare inherited neoplastic syndrome. Among all the VHLD-associated tumors, clear cell renal cell carcinoma (ccRCC) is the major cause of death. Objective: The aim of this paper is the discovery of new non-invasive biomarker for the monitoring of VHLD patients. Materials and methods: We compared the urinary proteome of VHLD patients, ccRCC patients and healthy volunteers. Results: Among all differentially expressed proteins, alpha-1-antitrypsin (A1AT) and APOH (beta-2-glycoprotein-1) are strongly over-abundant only in the urine of VHLD patients with a history of ccRCC. Discussion and conclusion: A1AT and APOH could be promising non-invasive biomarkers.

Beta-2-glycoprotein-1 and alpha-1-antitrypsin as urinary markers of renal cancer in von Hippel–Lindau patients

MANDILI, GIORGIA;NOTARPIETRO, AGATA;KHADJAVI, AMINA;ALLASIA, MARCO;BATTAGLIA, Antonino;LUCATELLO, Barbara;FREA, Bruno;TURRINI, Francesco Michelangelo;NOVELLI, Francesco;GIRIBALDI, Giuliana;DESTEFANIS, Paolo Giuseppe
2018

Abstract

Context: Von Hippel–Lindau disease (VHLD) is a rare inherited neoplastic syndrome. Among all the VHLD-associated tumors, clear cell renal cell carcinoma (ccRCC) is the major cause of death. Objective: The aim of this paper is the discovery of new non-invasive biomarker for the monitoring of VHLD patients. Materials and methods: We compared the urinary proteome of VHLD patients, ccRCC patients and healthy volunteers. Results: Among all differentially expressed proteins, alpha-1-antitrypsin (A1AT) and APOH (beta-2-glycoprotein-1) are strongly over-abundant only in the urine of VHLD patients with a history of ccRCC. Discussion and conclusion: A1AT and APOH could be promising non-invasive biomarkers.
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http://www.tandfonline.com/doi/full/10.1080/1354750X.2016.1269132
beta-2-glycoprotein-1 and alpha-1-antitrypsin; proteomics; renal cancer; urine; Von Hippel–Lindau disease; Biochemistry; Clinical Biochemistry; Health, Toxicology and Mutagenesis
Mandili, Giorgia; Notarpietro, Agata; Khadjavi, Amina; Allasia, Marco; Battaglia, Antonino; Lucatello, Barbara; Frea, Bruno; Turrini, Francesco; Novelli, Francesco; Giribaldi, Giuliana; Destefanis, Paolo
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1621432
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