Genistein is a natural xenoestrogen (isoflavonoid) that may interfere with the development of estrogen-sensitive neural circuits. Due to the large and increasing use of soy-based formulas for babies (characterized by a high content of genistein), there are some concerns that this could result in an impairment of some estrogen-sensitive neural circuits and behaviors. In a previous study, we demonstrated that its oral administration to female mice during late pregnancy and early lactation induced a significant decrease of nitric oxide synthase positive cells in the amygdala of their male offspring’s. In the present study, we have used a different experimental protocol mimicking, in mice, the direct precocious exposure to genistein. Mice pups of both sexes were fed either with oil, estradiol or genistein from birth to postnatal day 8. Nitric oxide synthase and vasopressin neural systems were analyzed in adult mice. Interestingly, we observed that genistein effect was time specific (when compared to our previous study), sex specific, and not always comparable to the effects of estradiol. This last observation suggests that genistein may act through different intracellular pathways. Present results indicate that the effect of natural xenoestrogens on the development of the brain may be highly variable: a plethora of neuronal circuits may be affected depending on sex, time of exposure, intracellular pathway involved, and target cells. This raises concern on the possible long-term effects of the use of soy-based formulas for babies, which may be currently underestimated.

Early postnatal genistein administration permanently affects nitrergic and vasopressinergic systems in a sex-specific way

PONTI, Giovanna;RODRIGUEZ GOMEZ, ALICIA;FARINETTI, ALICE;MARRAUDINO, MARILENA;FOGLIO, BENEDETTA;PANZICA, Giancarlo;GOTTI, STEFANO
Last
2017

Abstract

Genistein is a natural xenoestrogen (isoflavonoid) that may interfere with the development of estrogen-sensitive neural circuits. Due to the large and increasing use of soy-based formulas for babies (characterized by a high content of genistein), there are some concerns that this could result in an impairment of some estrogen-sensitive neural circuits and behaviors. In a previous study, we demonstrated that its oral administration to female mice during late pregnancy and early lactation induced a significant decrease of nitric oxide synthase positive cells in the amygdala of their male offspring’s. In the present study, we have used a different experimental protocol mimicking, in mice, the direct precocious exposure to genistein. Mice pups of both sexes were fed either with oil, estradiol or genistein from birth to postnatal day 8. Nitric oxide synthase and vasopressin neural systems were analyzed in adult mice. Interestingly, we observed that genistein effect was time specific (when compared to our previous study), sex specific, and not always comparable to the effects of estradiol. This last observation suggests that genistein may act through different intracellular pathways. Present results indicate that the effect of natural xenoestrogens on the development of the brain may be highly variable: a plethora of neuronal circuits may be affected depending on sex, time of exposure, intracellular pathway involved, and target cells. This raises concern on the possible long-term effects of the use of soy-based formulas for babies, which may be currently underestimated.
346
203
215
http://www.sciencedirect.com/science/article/pii/S0306452217300374
phytoestrogens, endocrine disruptors, sexual dimorphism, hypothalamus, limbic system
Ponti G; Rodriguez-Gomez A; Farinetti A; Marraudino M; Filice F; Foglio B; Sciacca G; Panzica GC; Gotti S
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0306452217300374-main.pdf

Accesso riservato

Descrizione: 2017PontiNS.pdf
Tipo di file: PDF EDITORIALE
Dimensione 3.44 MB
Formato Adobe PDF
3.44 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Ponti revised_4aperto.pdf

Accesso aperto con embargo fino al 01/02/2018

Descrizione: 2017PontiNS-aperto.pdf
Tipo di file: POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione 678.21 kB
Formato Adobe PDF
678.21 kB Adobe PDF Visualizza/Apri
2017Ponti_NS.pdf

Accesso riservato

Tipo di file: PDF EDITORIALE
Dimensione 3.44 MB
Formato Adobe PDF
3.44 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1629300
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 13
  • ???jsp.display-item.citation.isi??? 14
social impact