Post-traumatic stress disorder (PTSD) is a mental disorder that can develop after a person is exposed to a stressful life event, that involved real or symbolic survive treat. It is characterized by an emotional alteration that not recover spontaneously. This disorder is mainly conceived within the fear conditioning model, where the fear conditioned response fails to extinguish. The current hypothesis on PTSD is a learned incapacity of top-down structures as prefrontal cortex in inhibition of an “hyper-reactive” amygdala. The aim of this review is to consider all cerebral structures involved in PTSD and to suggest an alternative hypothesis on PTSD, in a bottom-up frame. Hyper-reactivity of amygdala could be linked to prefrontal deficits but also to the functioning of others cerebral structures as cerebellum. In fact both amygdala and cerebellum are crucial sites in fear conditioning and extinction models.
Neurobiological correlates of Post-traumatic Stress Disorder: a focus on cerebellum role.
Carletto, Sara;
2017-01-01
Abstract
Post-traumatic stress disorder (PTSD) is a mental disorder that can develop after a person is exposed to a stressful life event, that involved real or symbolic survive treat. It is characterized by an emotional alteration that not recover spontaneously. This disorder is mainly conceived within the fear conditioning model, where the fear conditioned response fails to extinguish. The current hypothesis on PTSD is a learned incapacity of top-down structures as prefrontal cortex in inhibition of an “hyper-reactive” amygdala. The aim of this review is to consider all cerebral structures involved in PTSD and to suggest an alternative hypothesis on PTSD, in a bottom-up frame. Hyper-reactivity of amygdala could be linked to prefrontal deficits but also to the functioning of others cerebral structures as cerebellum. In fact both amygdala and cerebellum are crucial sites in fear conditioning and extinction models.File | Dimensione | Formato | |
---|---|---|---|
manuscript post rev.doc
Accesso aperto
Tipo di file:
POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione
82 kB
Formato
Microsoft Word
|
82 kB | Microsoft Word | Visualizza/Apri |
Carletto & Borsato 2017.pdf
Accesso riservato
Tipo di file:
PDF EDITORIALE
Dimensione
336.71 kB
Formato
Adobe PDF
|
336.71 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.