Mesenchymal stem cells (MSCs) can exert an immunosuppressive effect on any component of the immune system, including dendritic cells (DCs), by direct contact, the release of soluble markers and extracellular vesicles (EVs). We evaluated whether MSCs and MSC-derived EVs have an immunomodulatory effect on monocyte-derived DCs in type 1 diabetes.

Human mesenchymal stem cells and derived extracellular vesicles induce regulatory dendritic cells in type 1 diabetic patients

FAVARO, Enrica;CARPANETTO, ANDREA;CAORSI, Cristiana;GIOVARELLI, Mirella;ANGELINI, COSTANZA;CAVALLO PERIN, Paolo;CAMUSSI, Giovanni;
2016

Abstract

Mesenchymal stem cells (MSCs) can exert an immunosuppressive effect on any component of the immune system, including dendritic cells (DCs), by direct contact, the release of soluble markers and extracellular vesicles (EVs). We evaluated whether MSCs and MSC-derived EVs have an immunomodulatory effect on monocyte-derived DCs in type 1 diabetes.
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Cytokines; Dendritic cells; Extracellular vesicles; GAD; Mesenchymal stem cells; Prostaglandin E2; T cells; Type 1 diabetes
Favaro, Enrica; Carpanetto, Andrea; Caorsi, Cristiana; Giovarelli, Mirella; Angelini, Costanza; Cavallo-Perin, Paolo; Tetta, Ciro; Camussi, Giovanni; Zanone, Maria M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1633748
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