A growing bulk of evidence suggests that cholesterol oxidation products, known as oxysterols, and 4-hydroxy-2-nonenal (HNE), the major proatherogenic components of oxidized low density lipoproteins (oxLDLs), significantly contribute to atherosclerotic plaque progression and destabilization, with eventual plaque rupture. These oxidized lipids are involved in various key steps of this complex process, mainly thanks to their ability to induce inflammation, oxidative stress, and apoptosis. This review summarizes the current knowledge of the effects induced by these compounds on vascular cells, after their accumulation in the arterial wall and in the atherosclerotic plaque.

Oxysterols and 4-hydroxy-2-nonenal contribute to atherosclerotic plaque destabilization.

GARGIULO, Simona;TESTA, GABRIELLA;GAMBA, Paola Francesca;STAURENGHI, ERICA;POLI, Giuseppe;LEONARDUZZI, Gabriella Marisa
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2017-01-01

Abstract

A growing bulk of evidence suggests that cholesterol oxidation products, known as oxysterols, and 4-hydroxy-2-nonenal (HNE), the major proatherogenic components of oxidized low density lipoproteins (oxLDLs), significantly contribute to atherosclerotic plaque progression and destabilization, with eventual plaque rupture. These oxidized lipids are involved in various key steps of this complex process, mainly thanks to their ability to induce inflammation, oxidative stress, and apoptosis. This review summarizes the current knowledge of the effects induced by these compounds on vascular cells, after their accumulation in the arterial wall and in the atherosclerotic plaque.
2017
111
140
150
atherosclerosis, oxysterols, HNE
Gargiulo, Simona; Testa, Gabriella; Gamba, Paola Francesca; Staurenghi, Erica; Poli, Giuseppe; Leonarduzzi, Gabriella Marisa
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1634669
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