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EnglishNutrient deprivation, hypoxia, radiotherapy and chemotherapy induce endoplasmic reticulum (ER) stress, which activates the so-called unfolded protein response (UPR). Extensive and acute ER stress directs the UPR towards activation of death-triggering pathways. Cancer cells are selected to resist mild and prolonged ER stress by activating pro-survival UPR. We recently found that drug-resistant tumor cells are simultaneously resistant to ER stress-triggered cell death. It is not known if cancer cells adapted to ER stressing conditions acquire a chemoresistant phenotype.
| Titolo: | PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy |
| Autori Riconosciuti: | |
| Autori: | Salaroglio, Iris C; Panada, Elisa; Moiso, Enrico; Buondonno, Ilaria; Provero, Paolo; Rubinstein, Menachem; Kopecka, Joanna; Riganti, Chiara |
| Data di pubblicazione: | 2017 |
| Abstract: | Nutrient deprivation, hypoxia, radiotherapy and chemotherapy induce endoplasmic reticulum (ER) stress, which activates the so-called unfolded protein response (UPR). Extensive and acute ER stress directs the UPR towards activation of death-triggering pathways. Cancer cells are selected to resist mild and prolonged ER stress by activating pro-survival UPR. We recently found that drug-resistant tumor cells are simultaneously resistant to ER stress-triggered cell death. It is not known if cancer cells adapted to ER stressing conditions acquire a chemoresistant phenotype. |
| Volume: | 16 |
| Fascicolo: | 1 |
| Pagina iniziale: | 91 |
| Pagina finale: | 103 |
| Digital Object Identifier (DOI): | 10.1186/s12943-017-0657-0 |
| Parole Chiave: | Chemoresistance; Endoplasmic reticulum stress; Eukaryotic translation initiation factor-2α kinase 3/protein kinase RNA-like endoplasmic reticulum kinase; Multidrug resistance related protein 1; Unfolded protein response |
| Rivista: | MOLECULAR CANCER |
| Appare nelle tipologie: | 03A-Articolo su Rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Salaroglio and Panada, Mol Cancer MS and Supplementary, 2017.pdf | salaroglio, manoscritto e supplementary information, Mol Cancer 2017 | 2 PDF Editoriale | Open Access Visualizza/Apri |
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