Nutrient deprivation, hypoxia, radiotherapy and chemotherapy induce endoplasmic reticulum (ER) stress, which activates the so-called unfolded protein response (UPR). Extensive and acute ER stress directs the UPR towards activation of death-triggering pathways. Cancer cells are selected to resist mild and prolonged ER stress by activating pro-survival UPR. We recently found that drug-resistant tumor cells are simultaneously resistant to ER stress-triggered cell death. It is not known if cancer cells adapted to ER stressing conditions acquire a chemoresistant phenotype.
PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy
SALAROGLIO, IRIS CHIARA;PANADA, ELISA;MOISO, ENRICO;BUONDONNO, ILARIA;PROVERO, Paolo;KOPECKA, JOANNA
Co-last
;RIGANTI, Chiara
Co-last
2017-01-01
Abstract
Nutrient deprivation, hypoxia, radiotherapy and chemotherapy induce endoplasmic reticulum (ER) stress, which activates the so-called unfolded protein response (UPR). Extensive and acute ER stress directs the UPR towards activation of death-triggering pathways. Cancer cells are selected to resist mild and prolonged ER stress by activating pro-survival UPR. We recently found that drug-resistant tumor cells are simultaneously resistant to ER stress-triggered cell death. It is not known if cancer cells adapted to ER stressing conditions acquire a chemoresistant phenotype.File in questo prodotto:
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Salaroglio and Panada, Mol Cancer MS and Supplementary, 2017.pdf
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Descrizione: salaroglio, manoscritto e supplementary information, Mol Cancer 2017
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