Backround: Political and sociocultural differences between countries can affect the outcome of clinical and epidemiological studies in ALS. Cross-national studies represent the ideal process by which risk factors can be assessed using the same methodology in different geographical areas. Methods: A survey of three European countries (The Netherlands, Ireland and Italy) has been conducted in which incident ALS patients and matched controls were recruited in a population-based study based on age, gender and area of residency, under the Euro-MOTOR systems biology programme of research. Findings: We have identified strengths and limitations during the trajectory of the Euro-MOTOR study, from the research design to data analysis. We have analysed the implications of factors including cross-national differences in healthcare systems, sample size, types of matching, the definition of exposures and statistical analysis. Conclusions: Addressing critical methodological aspects of the design of the Euro-MOTOR project minimises bias and will facilitate scientific assessment of the independent role of well-defined exposures.

Critical issues in ALS case-control studies: the case of the Euro-MOTOR study

D'OVIDIO, FABRIZIO;CHIO', Adriano;
2017

Abstract

Backround: Political and sociocultural differences between countries can affect the outcome of clinical and epidemiological studies in ALS. Cross-national studies represent the ideal process by which risk factors can be assessed using the same methodology in different geographical areas. Methods: A survey of three European countries (The Netherlands, Ireland and Italy) has been conducted in which incident ALS patients and matched controls were recruited in a population-based study based on age, gender and area of residency, under the Euro-MOTOR systems biology programme of research. Findings: We have identified strengths and limitations during the trajectory of the Euro-MOTOR study, from the research design to data analysis. We have analysed the implications of factors including cross-national differences in healthcare systems, sample size, types of matching, the definition of exposures and statistical analysis. Conclusions: Addressing critical methodological aspects of the design of the Euro-MOTOR project minimises bias and will facilitate scientific assessment of the independent role of well-defined exposures.
18
5-6
411
418
http://www.tandfonline.com/doi/full/10.1080/21678421.2017.1285939
Epidemiology, case-control study, risk, criticisms, genetics
D'Ovidio, Fabrizio; Rooney, James PK; Visser, Anne E; Vermeulen, Roel CH; Veldink, Jan H; van den Berg, Leonard H; Hardiman, Orla; Logroscino, Giancarlo; Chiò, Adriano; Beghi, Ettore.
File in questo prodotto:
File Dimensione Formato  
s1-ln2463499595844769-1939656818Hwf-922118750IdV125471858124634995PDF_HI0001.pdf

Accesso riservato

Descrizione: EM_methods_paper_pre_print
Tipo di file: PREPRINT (PRIMA BOZZA)
Dimensione 719.23 kB
Formato Adobe PDF
719.23 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1642962
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 16
  • ???jsp.display-item.citation.isi??? 14
social impact