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EnglishThe aim was to assess the activity of cisplatin (CDDP) in Ewing sarcoma (ES). The study consisted of front-line window therapy with CDDP 120 mg/sqm every 3 weeks for two courses in children and young adults with primary disseminated ES. Response was assessed using the Response Evaluation Criteria in Solid Tumours criteria, and Simon's two-stage design was applied. Twelve consecutive patients were enrolled in stage 1. Only one objective response was observed. Since the target response rate was not achieved, accrual was stopped and CDDP as a single agent in ES was judged unworthy of further assessment.
| Titolo: | Front-line window therapy with cisplatin in patients with primary disseminated Ewing sarcoma: A study by the Associazione Italiana di Ematologia ed Oncologia Pediatrica and Italian Sarcoma Group | |
| Autori Riconosciuti: | ||
| Autori: | Luksch, Roberto; Grignani, Giovanni; D'Angelo, Paolo; Prete, Arcangelo; Puma, Nadia; Podda, Marta; Casanova, Michela; Ferrari, Andrea; Morosi, Carlo; Fagioli, Franca; Aglietta, Massimo; Ferrari, Stefano; Picci, Piero; Massimino, Maura | |
| Data di pubblicazione: | 2017 | |
| Abstract: | The aim was to assess the activity of cisplatin (CDDP) in Ewing sarcoma (ES). The study consisted of front-line window therapy with CDDP 120 mg/sqm every 3 weeks for two courses in children and young adults with primary disseminated ES. Response was assessed using the Response Evaluation Criteria in Solid Tumours criteria, and Simon's two-stage design was applied. Twelve consecutive patients were enrolled in stage 1. Only one objective response was observed. Since the target response rate was not achieved, accrual was stopped and CDDP as a single agent in ES was judged unworthy of further assessment. | |
| Volume: | Jun 14 | |
| Pagina iniziale: | e26650 | |
| Pagina finale: | 26650 | |
| Digital Object Identifier (DOI): | 10.1002/pbc.26650 | |
| Parole Chiave: | Ewing sarcoma; cisplatin; metastatic | |
| Rivista: | PEDIATRIC BLOOD & CANCER | |
| Appare nelle tipologie: | 03A-Articolo su Rivista |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| cisplatinum definitivo.pdf | PREPRINT (PRIMA BOZZA) | Open Access Visualizza/Apri | ||
| pbc.26650.pdf | PDF EDITORIALE | Utenti riconosciuti Richiedi una copia |
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