Few data are available concerning the roles of polymorphisms of inosine triphosphatase (ITPA) gene and ribavirin (RBV) transporter genes in the prediction of RBV-induced anemia among Egyptians with chronic hepatitis C (CHC). Genotyping of 3 ITPA gene variants and 2 variants of RBV transporter genes has been performed in 123 patients under pegylated interferon-α/ribavirin treatment. The baseline hemoglobin and ITPA rs1127354 CA/AA have been found as predictors of anemia at 4, 8 and 12 weeks of RBV therapy. In addition, ITPA rs7270101 AC/CC and age predicted anemia after 12 weeks of therapy. In conclusion, the ITPA variant rs1127354C>A significantly predict RBV-induced anemia during the first 3 months of treatment and it is recommended to be assessed before RBV administration. This article is protected by copyright. All rights reserved.

The role of ITPA and ribavirin transporter genes polymorphisms in prediction of ribavirin-induced anemia in chronic hepatitis C Egyptian patients

CUSATO, JESSICA;DE NICOLO', AMEDEO;DI PERRI, Giovanni;D'AVOLIO, ANTONIO
Last
2017-01-01

Abstract

Few data are available concerning the roles of polymorphisms of inosine triphosphatase (ITPA) gene and ribavirin (RBV) transporter genes in the prediction of RBV-induced anemia among Egyptians with chronic hepatitis C (CHC). Genotyping of 3 ITPA gene variants and 2 variants of RBV transporter genes has been performed in 123 patients under pegylated interferon-α/ribavirin treatment. The baseline hemoglobin and ITPA rs1127354 CA/AA have been found as predictors of anemia at 4, 8 and 12 weeks of RBV therapy. In addition, ITPA rs7270101 AC/CC and age predicted anemia after 12 weeks of therapy. In conclusion, the ITPA variant rs1127354C>A significantly predict RBV-induced anemia during the first 3 months of treatment and it is recommended to be assessed before RBV administration. This article is protected by copyright. All rights reserved.
2017
44
9
965
968
ITPA; SLC28A3; SLC29A1; Ribavirin; anemia; pharmacogenetics
El Desoky, Ehab S; Abdelhafez, Alaa T; Cusato, Jessica; Kamel, Sherif I; Hussein, Abeer M. R; DE NICOLO', Amedeo; DI PERRI, Giovanni; D'Avolio, Antonio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1645747
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