Cognitive impairment is a common consequence of human immunodeficiency virus (HIV) infection, and dementia is one of the diseases that defines the acquired immunodeficiency syndrome. Peptide T (d-ala-peptide-T-amide) has been reported to block the binding of gp120 to brain tissue and to protect neurons from the toxic effects of gp120 in vitro. In pilot studies, administration of peptide T to HIV-positive patients with cognitive impairment was associated with improvement in cognition and constitutional symptoms.

Randomized double-blind placebo-controlled trial of peptide T for HIV-associated cognitive impairment

VITIELLO, BENEDETTO;SCHNEIDER, ROMINA LISBETH;
1998-01-01

Abstract

Cognitive impairment is a common consequence of human immunodeficiency virus (HIV) infection, and dementia is one of the diseases that defines the acquired immunodeficiency syndrome. Peptide T (d-ala-peptide-T-amide) has been reported to block the binding of gp120 to brain tissue and to protect neurons from the toxic effects of gp120 in vitro. In pilot studies, administration of peptide T to HIV-positive patients with cognitive impairment was associated with improvement in cognition and constitutional symptoms.
1998
55
1
41
51
AIDS Dementia Complex; Administration, Intranasal; Adolescent; Adult; CD4 Lymphocyte Count; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Peptide T; Treatment Outcome
Heseltine, P N; Goodkin, K; Atkinson, J H; Vitiello, B; Rochon, J; Heaton, R K; Eaton, E M; Wilkie, F L; Sobel, E; Brown, S J; Feaster, D; Schneider, L; Goldschmidts, W L; Stover, E S
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1646455
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