Mitotane is the reference drug for the adrenocortical carcinoma treatment; its pharmacological activity seems to depend on drug transformation in two active metabolites: o,p'-DDE (dichlorodiphenylethene) and o,p'-DDA (dichlorodiphenylacetate). Mitotane and metabolites are lipophilic agents; thus, they tend to accumulate into adipose tissues (white and brown), which change their prevalence seasonally. Aim of the work was to evaluate mitotane and metabolites plasma levels variation over the year, in adrenocortical cancer patients treated with Lysodren(®) for at least 6 months.

Circannual variation of mitotane and its metabolites plasma levels in patients with adrenocortical carcinoma

CUSATO, JESSICA
Co-first
;
DE FRANCIA, SILVIA
Co-first
;
ALLEGRA, SARAH;PIRRO, Elisa;DAFFARA, Fulvia Claudia;TERZOLO, Massimo;BERRUTI, Alfredo;DI CARLO, Francesco;TAMPELLINI, MARCO;D'AVOLIO, ANTONIO
Last
2017

Abstract

Mitotane is the reference drug for the adrenocortical carcinoma treatment; its pharmacological activity seems to depend on drug transformation in two active metabolites: o,p'-DDE (dichlorodiphenylethene) and o,p'-DDA (dichlorodiphenylacetate). Mitotane and metabolites are lipophilic agents; thus, they tend to accumulate into adipose tissues (white and brown), which change their prevalence seasonally. Aim of the work was to evaluate mitotane and metabolites plasma levels variation over the year, in adrenocortical cancer patients treated with Lysodren(®) for at least 6 months.
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DDD; HPLC; Therapeutic Drug Monitoring; adrenocortical carcinoma; gender medicine; seasons
Cusato, Jessica; DE FRANCIA, Silvia; Allegra, Sarah; Carrella, Simona; Pirro, Elisa; Piccione, Francesca Maria; De Martino, Francesca; Ferrero, Anna; Daffara, Fulvia Claudia; Terzolo, Massimo; Berruti, Alfredo; DI CARLO, Francesco; Tampellini, Marco; D'Avolio, Antonio
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1650599
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