The ecto-5’-nucleotidase/CD73 enzyme plays a pivotal role in generating an adenosine-enriched immunosuppressed and pro-angiogenic niche supporting cancer development. The targeting of CD73 leads to reorganization of tumor microenvironment, shaping the phenotype of the infiltrating T cells. The development of CD73 monoclonal antibodies offers a promising new avenue for antineoplastic treatment.

Anti-CD73 immunotherapy: A viable way to reprogram the tumor microenvironment

Malavasi, Fabio;
2016-01-01

Abstract

The ecto-5’-nucleotidase/CD73 enzyme plays a pivotal role in generating an adenosine-enriched immunosuppressed and pro-angiogenic niche supporting cancer development. The targeting of CD73 leads to reorganization of tumor microenvironment, shaping the phenotype of the infiltrating T cells. The development of CD73 monoclonal antibodies offers a promising new avenue for antineoplastic treatment.
2016
5
9
1
3
10.1080/2162402X.2016.1216292
CD73; monoclonal antibody; tumor microenvironment; immunotherapy; autophagy
Antonioli, Luca; Blandizzi C, Corrado; Malavasi, Fabio; Ferrari, Davide; Haskó, György
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1654373
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