Cerebral vasospasm represents the most critical event that could occur after subarachnoid hemorrhage (SAH). Therapy is only partially effective because cerebral arterial constriction is not fully understood yet. One of the most important biological messenger associated to SAH is nitric oxide (NO), that is considered local regulator of cerebral blood flow. Different nitric oxide synthase (NOS) forms play a role in different biological processes, one of which is to link neuronal activity to blood flow in cerebral cortex. We performed a reassessment of the literature to summarize the role of NO as the main inflammatory pathway activated after SAH to clarify its importance for treatment of vasospasm.

Role of nitric oxide and mechanisms involved in cerebral injury after subarachnoid hemorrhage: is nitric oxide a possible answer to cerebral vasospasm?

Crobeddu, Emanuela;Pilloni, Giulia;Tardivo, Valentina;Fontanella, Marco M;Panciani, Pier P;Fornaro, Riccardo;Altieri, Roberto;Agnoletti, Alessandro;Ajello, Marco;Zenga, Francesco;Ducati, Alessandro;Garbossa, Diego
2016

Abstract

Cerebral vasospasm represents the most critical event that could occur after subarachnoid hemorrhage (SAH). Therapy is only partially effective because cerebral arterial constriction is not fully understood yet. One of the most important biological messenger associated to SAH is nitric oxide (NO), that is considered local regulator of cerebral blood flow. Different nitric oxide synthase (NOS) forms play a role in different biological processes, one of which is to link neuronal activity to blood flow in cerebral cortex. We performed a reassessment of the literature to summarize the role of NO as the main inflammatory pathway activated after SAH to clarify its importance for treatment of vasospasm.
60
3
385
391
Animals; Brain Injuries; Cerebrovascular Circulation; Humans; Nitric Oxide; Nitric Oxide Synthase; Subarachnoid Hemorrhage; Vasospasm, Intracranial
Crobeddu, Emanuela; Pilloni, Giulia; Tardivo, Valentina; Fontanella, Marco M; Panciani, Pier P; Spena, Giannantonio; Fornaro, Riccardo; Altieri, Roberto; Agnoletti, Alessandro; Ajello, Marco; Zenga, Francesco; Ducati, Alessandro; Garbossa, Diego
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1657941
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 6
social impact