Canonical Wnt/beta-catenin signalling regulates self-renewal and lineage selection within the mammalian epidermis. Although the transcriptional response of keratinocytes that receive a Wnt signal is well characterized, little is known about the mechanism by which keratinocytes in proximity to the Wnt-receiving cell are co-opted to undergo a change in cell fate.

Epidermal Wnt signalling regulates transcriptome heterogeneity and proliferative fate in neighbouring cells

Donati, Giacomo;
2018-01-01

Abstract

Canonical Wnt/beta-catenin signalling regulates self-renewal and lineage selection within the mammalian epidermis. Although the transcriptional response of keratinocytes that receive a Wnt signal is well characterized, little is known about the mechanism by which keratinocytes in proximity to the Wnt-receiving cell are co-opted to undergo a change in cell fate.
2018
19
1
1
14
Ghahramani, Arsham; Donati, Giacomo; Luscombe, Nicholas M; Watt, Fiona M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1658034
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