Acquired resistance to anti-EGFR therapy (epidermal growth factor receptor) is frequently due to RAS and EGFR extracellular domain (ECD) mutations in metastatic colorectal cancer (mCRC). Some anti-EGFR-refractory patients retain tumor EGFR dependency potentially targetable by agents such as Sym004, which is a mixture of 2 nonoverlapping monoclonal antibodies targeting EGFR.

Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses: A Phase 2 Randomized Clinical Trial

Rospo, Giuseppe;Bardelli, Alberto
Co-last
;
2018-01-01

Abstract

Acquired resistance to anti-EGFR therapy (epidermal growth factor receptor) is frequently due to RAS and EGFR extracellular domain (ECD) mutations in metastatic colorectal cancer (mCRC). Some anti-EGFR-refractory patients retain tumor EGFR dependency potentially targetable by agents such as Sym004, which is a mixture of 2 nonoverlapping monoclonal antibodies targeting EGFR.
2018
e175245
-
https://jamanetwork.com/journals/jamaoncology/fullarticle/2671608
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885274/
Montagut, Clara; Argilés, Guillem; Ciardiello, Fortunato; Poulsen, Thomas T; Dienstmann, Rodrigo; Kragh, Michael; Kopetz, Scott; Lindsted, Trine; Ding, Cliff; Vidal, Joana; Clausell-Tormos, Jenifer; Siravegna, Giulia; Sánchez-Martín, Francisco J; Koefoed, Klaus; Pedersen, Mikkel W; Grandal, Michael M; Dvorkin, Mikhail; Wyrwicz, Lucjan; Rovira, Ana; Cubillo, Antonio; Salazar, Ramon; Desseigne, Françoise; Nadal, Cristina; Albanell, Joan; Zagonel, Vittorina; Siena, Salvatore; Fumi, Guglielmo; Rospo, Giuseppe; Nadler, Paul; Horak, Ivan D; Bardelli, Alberto; Tabernero, Josep
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1660159
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