BACKGROUND: The purpose of this retrospective study was to identify subcategories in cT3 to cT4a supraglottic/glottic cancers, describing their different spreading patterns, and local and locoregional recurrence modes. METHODS: Four hundred eighty-nine patients who underwent open partial horizontal laryngectomies (OPHLs) were retrospectively classified as: subcategory I (anterior pT3 with normal arytenoid mobility); subcategory II (posterior pT3 with impaired/absent mobility); subcategory III (anterior pT4 with normal mobility); and subcategory IV (posterior pT4 with impaired/absent mobility). RESULTS: Five-year overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), locoregional, local control, freedom from laryngectomy, and laryngectomy-free survival were significantly better in anterior tumors (subcategories I and III) when compared with the corresponding posterior ones (subcategories II and IV). CONCLUSION: Anterior cT3 tumors are manageable by OPHL, and this approach could also be proposed in the treatment of early anterior cT4aN0. Despite promising results, OPHLs should be considered under investigation in posterior cT3 tumors due to clinical and biological behavior similar to cT4a tumors.

Treatment of T3-T4a laryngeal cancer by open partial horizontal laryngectomies: prognostic impact of different pT subcategories

Succo Giovanni
First
;
Crosetti Erika;Cirillo Stefano;Petracchini Massimo;TASCONE, MARTINA;Sprio Andrea Elio;Berta Giovanni Nicolao;
2018-01-01

Abstract

BACKGROUND: The purpose of this retrospective study was to identify subcategories in cT3 to cT4a supraglottic/glottic cancers, describing their different spreading patterns, and local and locoregional recurrence modes. METHODS: Four hundred eighty-nine patients who underwent open partial horizontal laryngectomies (OPHLs) were retrospectively classified as: subcategory I (anterior pT3 with normal arytenoid mobility); subcategory II (posterior pT3 with impaired/absent mobility); subcategory III (anterior pT4 with normal mobility); and subcategory IV (posterior pT4 with impaired/absent mobility). RESULTS: Five-year overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), locoregional, local control, freedom from laryngectomy, and laryngectomy-free survival were significantly better in anterior tumors (subcategories I and III) when compared with the corresponding posterior ones (subcategories II and IV). CONCLUSION: Anterior cT3 tumors are manageable by OPHL, and this approach could also be proposed in the treatment of early anterior cT4aN0. Despite promising results, OPHLs should be considered under investigation in posterior cT3 tumors due to clinical and biological behavior similar to cT4a tumors.
2018
40
9
1897
1908
https://onlinelibrary.wiley.com/doi/full/10.1002/hed.25176
T3 laryngeal cancer, T4 laryngeal cancer, open partial horizontal laryngectomy, supracricoid partial laryngectomy, supratracheal partial laryngectomy
Succo Giovanni, Crosetti Erika, Bertolin Andy, Piazza Cesare, Molteni Gabriele, Cirillo Stefano, Petracchini Massimo, Tascone Martina, Sprio Andrea Elio, Berta Giovanni Nicolao, Peretti Giorgio, Presutti Livio, Rizzotto Giuseppe.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1660699
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