Autoimmune diseases are a diverse group of chronic disorders and affect a multitude of organs and systems. However, the existence of common pathophysiological mech- anisms is hypothesized and reports of shared risk are emerging as well. In this regard, patients with multiple sclerosis (MS) have been shown to have an increased susceptibility to develop chronic autoimmune thyroid diseases, in particular Hashimoto’s thyroiditis (HT), suggesting an autoimmune predisposition. However, studies comparing such different pathologies of autoimmune origin are still missing till date. In the present study, we sought to investigate mechanisms which may lead to the frequent coexistence of MS and HT by analyzing several factors related to the pathogenesis of MS and HT in patients affected by one or both diseases, as well as in healthy donors. In particular, we analyzed peripheral blood mononuclear cell gene-expression levels of common candidate genes such as TNFAIP3, NR4A family, BACH2, FOXP3, and PDCD5, in addition to the regu- latory T cell (Treg) percentage and the 25-hydroxy vitamin D serum levels. Our ndings support the plausibility of the existence of common deregulated mechanisms shared by MS and HT, such as BACH2/PDCD5-FOXP3 pathways and Tregs. Although the biolog- ical implications of these data need to be further investigated, we have highlighted the relevance of studies comparing different autoimmune pathologies for the understanding of the core concepts of autoimmunity.

The footprints of poly-autoimmunity: Evidence for common biological factors involved in multiple sclerosis and Hashimoto's thyroiditis

PERGA, SIMONA;Montarolo, Francesca;Spadaro, Michela;Corvisieri, Stefania;Messuti, Ilaria;Panzica, Giancarlo;Orlandi, Fabio;Bertolotto, Antonio
2018

Abstract

Autoimmune diseases are a diverse group of chronic disorders and affect a multitude of organs and systems. However, the existence of common pathophysiological mech- anisms is hypothesized and reports of shared risk are emerging as well. In this regard, patients with multiple sclerosis (MS) have been shown to have an increased susceptibility to develop chronic autoimmune thyroid diseases, in particular Hashimoto’s thyroiditis (HT), suggesting an autoimmune predisposition. However, studies comparing such different pathologies of autoimmune origin are still missing till date. In the present study, we sought to investigate mechanisms which may lead to the frequent coexistence of MS and HT by analyzing several factors related to the pathogenesis of MS and HT in patients affected by one or both diseases, as well as in healthy donors. In particular, we analyzed peripheral blood mononuclear cell gene-expression levels of common candidate genes such as TNFAIP3, NR4A family, BACH2, FOXP3, and PDCD5, in addition to the regu- latory T cell (Treg) percentage and the 25-hydroxy vitamin D serum levels. Our ndings support the plausibility of the existence of common deregulated mechanisms shared by MS and HT, such as BACH2/PDCD5-FOXP3 pathways and Tregs. Although the biolog- ical implications of these data need to be further investigated, we have highlighted the relevance of studies comparing different autoimmune pathologies for the understanding of the core concepts of autoimmunity.
9
FEB
311-1
311-12
https://www.frontiersin.org/articles/10.3389/fimmu.2018.00311/full
25-hydroxy vitamin D; Gene expression; Hashimoto's thyroiditis; Multiple sclerosis; Regulatory T cells; Immunology and Allergy; Immunology
Perga, Simona; Martire, Serena; Montarolo, Francesca; Giordani, Ilaria; Spadaro, Michela; Bono, Gabriele; Corvisieri, Stefania; Messuti, Ilaria; Panzica, Giancarlo; Orlandi, Fabio; Bertolotto, Antonio
File in questo prodotto:
File Dimensione Formato  
fimmu-09-00311.pdf

Accesso aperto

Descrizione: 2018PergaFrImmunol
Tipo di file: PDF EDITORIALE
Dimensione 2.33 MB
Formato Adobe PDF
2.33 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1661832
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 14
social impact