Abacavir is a widely used nucleotide reverse transcriptase inhibitor whose cerebrospinal fluid (CSF) exposure has been previously assessed in twice-daily recipients. We studied abacavir CSF concentrations in 61 and 9 HIV-positive once-daily and twice-daily abacavir intakers. Patients on once-daily abacavir had higher plasma and CSF concentrations (96 vs. 22 ng/mL, p=0.038 and 123 vs. 49 ng/mL, p=0.038) but similar CSF-to-plasma ratios (0.8 vs. 0.5, p=0.500). CSF abacavir concentrations were adequate in once-daily receiving patients.

Cerebrospinal Fluid Abacavir Concentrations in HIV-positive Patients Following Once-daily Administration

Calcagno, A
First
;
De Nicolò, A;D'Avolio Antonio;Di Perri, G;Bonora, S
Last
2018

Abstract

Abacavir is a widely used nucleotide reverse transcriptase inhibitor whose cerebrospinal fluid (CSF) exposure has been previously assessed in twice-daily recipients. We studied abacavir CSF concentrations in 61 and 9 HIV-positive once-daily and twice-daily abacavir intakers. Patients on once-daily abacavir had higher plasma and CSF concentrations (96 vs. 22 ng/mL, p=0.038 and 123 vs. 49 ng/mL, p=0.038) but similar CSF-to-plasma ratios (0.8 vs. 0.5, p=0.500). CSF abacavir concentrations were adequate in once-daily receiving patients.
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abacavir; age; central nervous system; cerebrospinal fluid; pharmacokinetics; protease inhibitors
Calcagno, A; Pinnetti, C; De Nicolò, A; Scarvaglieri, E; Gisslen, M; Tempestilli, M; D'Avolio Antonio; Fedele, V; Di Perri, G; Antinori, A; Bonora, S
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1664116
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