Through access to in vivo T1 measurements at low magnetic fields it was established that tumour cells display proton T1 values that are markedly longer than the those shown by healthy tissue. Moreover, it has been found that the elongation of T1 parallels the aggressiveness of the investigated tumour. The T1-lengthening is associated with an enhanced water exchange rate across the transcytolemmal membrane through an overexpression/upregulation of GLUT1 and Na+/K+ATPase transporters. It follows that the intracellular (IN) water lifetime represents a hallmark of tumour cells that can be easily monitored by measuring T1 at different magnetic field strengths ranging from 0.2 to 200 mT.

Evidence for the role of intracellular water lifetime as a tumour biomarker by in vivo Field-Cycling relaxometry

Ruggiero, Maria Rosaria;Baroni, Simona;Geninatti Crich, Simonetta
;
Aime, Silvio
2018-01-01

Abstract

Through access to in vivo T1 measurements at low magnetic fields it was established that tumour cells display proton T1 values that are markedly longer than the those shown by healthy tissue. Moreover, it has been found that the elongation of T1 parallels the aggressiveness of the investigated tumour. The T1-lengthening is associated with an enhanced water exchange rate across the transcytolemmal membrane through an overexpression/upregulation of GLUT1 and Na+/K+ATPase transporters. It follows that the intracellular (IN) water lifetime represents a hallmark of tumour cells that can be easily monitored by measuring T1 at different magnetic field strengths ranging from 0.2 to 200 mT.
2018
57
25
7468
7472
Fast Field Cycling relaxometry, intracellular water lifetime, T1 longitudinal relaxation time, breast tumour metabolic activity
Ruggiero, Maria Rosaria; Baroni, Simona; Pezzana, Stefania; Ferrante, Gianni; Geninatti Crich, Simonetta; Aime, Silvio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1666079
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