The aim of this survey was to describe the incidence, epidemiology, microbiology, risk factors and outcome of medical care related laboratory-confirmed bloodstream infections (LCBIs) observed during a twelve-month prospective study in a Paediatric Teaching Hospital in Turin, Italy. Inclusion criteria were clinical signs of sepsis and positivity of one or more of the following tests: blood culture, polymerase chain reaction for bacterial and fungal DNA on blood, and culture on intravascular device tips. In all, 140 episodes of sepsis were documented in 131 children: 37 (26.4%) were healthcare outpatient-associated, 91 (65.0%) healthcare-associated and 12 (8.6%) community-acquired. The overall incidence of healthcare-associated LCBIs was 13.6/1,000 hospitalized patients and incidence density 1.4/1,000 inpatient days. The overall mortality was 3.9%. Forty-seven (36.7%) episodes involved newborns and 107 (83.6%) episodes were observed in children with an indwelling central venous catheter. Coagulase-negative staphylococci (26.8%), Staphylococcus aureus (15.2%), Escherichia coli (8.7%) and Candida spp. (7.2%) were responsible for the majority of cases. 9.5% of S. aureus isolates were methicillin-resistant and 6.5% of Gram negatives were extended-spectrum beta-lactamase-producing. Incidence and epidemiology of medical care related LCBIs were similar to the existing literature data. LCBIs caused by antibiotic-resistant microorganisms were fewer and mortality rate was lower. Most of the LCBIs recorded involved newborns and oncological children.

Medical care related laboratory-confirmed bloodstream infections in paediatrics

Virano S;Garazzino S;Raffaldi I;Calitri C;Tovo PA;Zotti CM;Carraro F;Bertino E;Coscia A;Di Nicola P;Cerchio R;Bosetti FM;Manzoni P
2015-01-01

Abstract

The aim of this survey was to describe the incidence, epidemiology, microbiology, risk factors and outcome of medical care related laboratory-confirmed bloodstream infections (LCBIs) observed during a twelve-month prospective study in a Paediatric Teaching Hospital in Turin, Italy. Inclusion criteria were clinical signs of sepsis and positivity of one or more of the following tests: blood culture, polymerase chain reaction for bacterial and fungal DNA on blood, and culture on intravascular device tips. In all, 140 episodes of sepsis were documented in 131 children: 37 (26.4%) were healthcare outpatient-associated, 91 (65.0%) healthcare-associated and 12 (8.6%) community-acquired. The overall incidence of healthcare-associated LCBIs was 13.6/1,000 hospitalized patients and incidence density 1.4/1,000 inpatient days. The overall mortality was 3.9%. Forty-seven (36.7%) episodes involved newborns and 107 (83.6%) episodes were observed in children with an indwelling central venous catheter. Coagulase-negative staphylococci (26.8%), Staphylococcus aureus (15.2%), Escherichia coli (8.7%) and Candida spp. (7.2%) were responsible for the majority of cases. 9.5% of S. aureus isolates were methicillin-resistant and 6.5% of Gram negatives were extended-spectrum beta-lactamase-producing. Incidence and epidemiology of medical care related LCBIs were similar to the existing literature data. LCBIs caused by antibiotic-resistant microorganisms were fewer and mortality rate was lower. Most of the LCBIs recorded involved newborns and oncological children.
2015
23
2
117
124
Anti-Bacterial Agents; Bacteremia; Child; Child, Preschool; Cross Infection; Drug Resistance, Multiple, Bacterial; Female; Hospitals, Pediatric; Hospitals, Teaching; Humans; Incidence; Infant; Infant, Newborn; Intensive Care Units, Pediatric; Italy; Male; Methicillin-Resistant Staphylococcus aureus; Prospective Studies; Risk Factors; Staphylococcal Infections; Staphylococcus aureus; Pediatrics
Virano S; Scolfaro C; Garazzino S; De Intinis C; Ghisetti V; Raffaldi I; Calitri C; Tovo PA; Regina Margherita Children’s Hospital Bloodstream Infections Study Group including Plazzotta C; Zotti CM; Neve V; Conio A; Vitale P; Giacchino M; Bertin D; Carraro F; Le Serre D; Iannandrea S; Grassitelli SM; Luccoli L; Esposito I; Ragazzi P; Carlino C; Porcellini MG; Bonaudo R; Calvo PL; Baldi M; Laudati R; Ferraris S; Aidala E; Valori A; Banaudi E; Riggi C; Bertino E; Coscia A; Di Nicola P; Cavecchia I; Cerchio R; Bosetti FM; Bianciotto M; Farina D; Manzoni P
File in questo prodotto:
File Dimensione Formato  
InfezMed_2015.pdf

Accesso aperto

Tipo di file: PDF EDITORIALE
Dimensione 155.75 kB
Formato Adobe PDF
155.75 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1670202
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 4
  • ???jsp.display-item.citation.isi??? ND
social impact