Inflammation is a process that underlies sight-threatening ocular surface diseases, and gene supplementation with the plasmid that encodes for p-IL10 will allow the sustained de novo synthesis of the cytokine to occur in corneal cells, and provide a long-term anti-inflammatory effect. This work describes the development of solid lipid nanoparticle systems for the delivery of p-IL10 to transfect the cornea.
Gene delivery in the cornea: in vitro & ex vivo evaluation of solid lipid nanoparticle-based vectors
Serpe, Loredana;Foglietta, Federica;Muntoni, Elisabetta;Battaglia, LuigiLast
2018-01-01
Abstract
Inflammation is a process that underlies sight-threatening ocular surface diseases, and gene supplementation with the plasmid that encodes for p-IL10 will allow the sustained de novo synthesis of the cytokine to occur in corneal cells, and provide a long-term anti-inflammatory effect. This work describes the development of solid lipid nanoparticle systems for the delivery of p-IL10 to transfect the cornea.File in questo prodotto:
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articolo cornee plasmidi.pdf
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