Inflammation is a process that underlies sight-threatening ocular surface diseases, and gene supplementation with the plasmid that encodes for p-IL10 will allow the sustained de novo synthesis of the cytokine to occur in corneal cells, and provide a long-term anti-inflammatory effect. This work describes the development of solid lipid nanoparticle systems for the delivery of p-IL10 to transfect the cornea.

Gene delivery in the cornea: in vitro & ex vivo evaluation of solid lipid nanoparticle-based vectors

Serpe, Loredana;Foglietta, Federica;Muntoni, Elisabetta;Battaglia, Luigi
Last
2018

Abstract

Inflammation is a process that underlies sight-threatening ocular surface diseases, and gene supplementation with the plasmid that encodes for p-IL10 will allow the sustained de novo synthesis of the cytokine to occur in corneal cells, and provide a long-term anti-inflammatory effect. This work describes the development of solid lipid nanoparticle systems for the delivery of p-IL10 to transfect the cornea.
13
15
1847-1854
1854
cornea explant; corneal inflammation; corneal transfection; ex vivo; gene delivery; gene supplementation; in vitro; interleukin-10 gene; nonviral vectors; solid lipid nanoparticles
Vicente-Pascual, Mónica; Albano, Andrea; Solinís, María Á; Serpe, Loredana; Rodríguez-Gascón, Alicia; Foglietta, Federica; Muntoni, Elisabetta; Torrecilla, Josune; Pozo-Rodríguez, Ana Del; Battaglia, Luigi
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1677366
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