The PRESTO study of non-invasive vagus nerve stimulation (nVNS; gammaCore®) featured key primary and secondary end points recommended by the International Headache Society to provide Class I evidence that for patients with an episodic migraine, nVNS significantly increases the probability of having mild pain or being pain-free 2 h post stimulation. Here, we examined additional data from PRESTO to provide further insights into the practical utility of nVNS by evaluating its ability to consistently deliver clinically meaningful improvements in pain intensity while reducing the need for rescue medication.

Practical and clinical utility of non-invasive vagus nerve stimulation (nVNS) for the acute treatment of migraine: a post hoc analysis of the randomized, sham-controlled, double-blind PRESTO trial

Innocenzo Rainero;Sances G;Padovan AM;Ricci K;Cortelli P;Rainero I;De Martino P;Gai A;Govone F;Masuzzo F;Rubino E;Torrieri MC;Vacca A;Marone I;Simoni S;
2018

Abstract

The PRESTO study of non-invasive vagus nerve stimulation (nVNS; gammaCore®) featured key primary and secondary end points recommended by the International Headache Society to provide Class I evidence that for patients with an episodic migraine, nVNS significantly increases the probability of having mild pain or being pain-free 2 h post stimulation. Here, we examined additional data from PRESTO to provide further insights into the practical utility of nVNS by evaluating its ability to consistently deliver clinically meaningful improvements in pain intensity while reducing the need for rescue medication.
THE JOURNAL OF HEADACHE AND PAIN
19
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Migraine; Neuromodulation; Pain intensity; Post hoc analysis; Rescue medication; Vagus nerve stimulation
Licia GrazziEmail author, Cristina Tassorelli, Marina de Tommaso, Giulia Pierangeli, Paolo Martelletti, Innocenzo Rainero, Pierangelo Geppetti, Anna Ambrosini, Paola Sarchielli, Eric Liebler, Piero Barbanti PRESTO Study Group. Tassorelli C, Bitetto V, De Icco R, Martinelli D, Sances G, Bianchi M, Grazzi L, Padovan AM, de Tommaso M, Ricci K, Vecchio E, Cortelli P, Cevoli S, Pierangeli G, Terlizzi R, Martelletti P, Negro A, Chiariello GA, Rainero I, De Martino P, Gai A, Govone F, Masuzzo F, Rubino E, Torrieri MC, Vacca A, Geppetti P, Chiarugi A, De Cesaris F, Puma SL, Lupi C, Marone I, Ambrosini A, Perrotta A, Sarchielli P, Bernetti L, Corbelli I, Romoli M, Simoni S, Verzina A, Barbanti P, Aurilia C, Egeo G, Fofi L, Liebler E, Andersson A, Spitzer L, Marin J, McClure C, Thackeray L, Baldi MG, Di Maro D.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1678517
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