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EnglishObjectives: The detection of dyskinesias-reduced-self-awareness (DRSA), in Parkinson's disease (PD), was previously associated to executive and metacognitive deficits mainly due to dopaminergic overstimulation of mesocorticolimbic circuits. Response-inhibition dysfunction is often observed in PD. Apart from being engaged in response-inhibition tasks, the anterior cingulate cortex (ACC), is part of a functional system based on self-awareness and engaged across cognitive, affective and behavioural contexts. The purpose of the study was to examine the relationship between response-inhibition disabilities and DRSA using whole-brain event-related functional magnetic resonance imaging (fMRI), over the course of a specific executive task. Methods: Twenty-seven cognitively preserved idiopathic PD patients - presenting motor fluctuations and dyskinesias - were studied. They underwent a neurological and neuropsychological evaluation. The presence of DRSA was assessed using the Dyskinesias Subtracted-Index (DS-I). Cingulate functionality was evaluated with fMRI, while patients performed an ACC-sensitive GO-NoGO task. Association between blood oxygenation level dependent response over the whole-brain during the response-inhibition task and DS-I scores was investigated by regression analysis. Results: The presence of DRSA was associated with reduced functional recruitment in the bilateral ACC, bilateral anterior insular cortex and right dorsolateral prefrontal cortex (pFWE < 0.05). Moreover, DS-I scores significantly correlated with percent errors on the NoGO condition (r = 0.491, pFWE = 0.009). Discussion: These preliminary findings add evidence to the relevant role of executive dysfunctions in DRSA pathogenesis beyond the effects of chronic dopaminergic treatment, with a key leading role played by ACC as part of a functionally impaired response-inhibition network. Imaging biomarkers for DRSA are important to be studied, especially when the neuropsychological assessment seems to be normal
| Titolo: | Role of the cingulate cortex in dyskinesias-reduced-self-awareness: An fMRI study on Parkinson's disease patients | |
| Autori Riconosciuti: | ||
| Autori: | Palermo S, Lopiano L, Morese R, Zibetti M, Romagnolo A, Stanziano M, Rizzone MG, Geminiani GC, Valentini MC, Amanzio M. | |
| Data di pubblicazione: | 2018 | |
| Abstract: | Objectives: The detection of dyskinesias-reduced-self-awareness (DRSA), in Parkinson's disease (PD), was previously associated to executive and metacognitive deficits mainly due to dopaminergic overstimulation of mesocorticolimbic circuits. Response-inhibition dysfunction is often observed in PD. Apart from being engaged in response-inhibition tasks, the anterior cingulate cortex (ACC), is part of a functional system based on self-awareness and engaged across cognitive, affective and behavioural contexts. The purpose of the study was to examine the relationship between response-inhibition disabilities and DRSA using whole-brain event-related functional magnetic resonance imaging (fMRI), over the course of a specific executive task. Methods: Twenty-seven cognitively preserved idiopathic PD patients - presenting motor fluctuations and dyskinesias - were studied. They underwent a neurological and neuropsychological evaluation. The presence of DRSA was assessed using the Dyskinesias Subtracted-Index (DS-I). Cingulate functionality was evaluated with fMRI, while patients performed an ACC-sensitive GO-NoGO task. Association between blood oxygenation level dependent response over the whole-brain during the response-inhibition task and DS-I scores was investigated by regression analysis. Results: The presence of DRSA was associated with reduced functional recruitment in the bilateral ACC, bilateral anterior insular cortex and right dorsolateral prefrontal cortex (pFWE < 0.05). Moreover, DS-I scores significantly correlated with percent errors on the NoGO condition (r = 0.491, pFWE = 0.009). Discussion: These preliminary findings add evidence to the relevant role of executive dysfunctions in DRSA pathogenesis beyond the effects of chronic dopaminergic treatment, with a key leading role played by ACC as part of a functionally impaired response-inhibition network. Imaging biomarkers for DRSA are important to be studied, especially when the neuropsychological assessment seems to be normal | |
| Volume: | 9 | |
| Fascicolo: | SEP | |
| Pagina iniziale: | 1 | |
| Pagina finale: | 10 | |
| Digital Object Identifier (DOI): | 10.3389/fpsyg.2018.01765 | |
| URL: | https://www.frontiersin.org/articles/10.3389/fpsyg.2018.01765/full | |
| Parole Chiave: | Dyskinesias, FMRI, Parkinson's disease, Response-inhibition, Self-awareness, Psychology (all) | |
| Rivista: | FRONTIERS IN PSYCHOLOGY | |
| Appare nelle tipologie: | 03A-Articolo su Rivista |
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