Atazanavir/ritonavir concentrations change over pregnancy in HIV-positive patients; the impact of genetic variants is unknown. 20 patients were enrolled: antiretrovirals' plasma and intracellular concentrations were measured in addition to single nucleotide polymorphisms in transport affecting genes. Linear logistic regression showed that genetic variants in organic-anion-transporter-1B1 and pregnane-X-receptor encoding genes affected third trimester atazanavir exposure. In this prospective study genetic variants partially explained the observed inter-patient variability in third-trimester antiretrovirals' exposure.

Pharmacokinetic Changes during Pregnancy According to Genetic Variants: A Prospective Study in HIV-infected Patients Receiving Atazanavir/Ritonavir

Calcagno, Andrea;Cusato, Jessica;D'Avolio, Antonio;Trentini, Laura;Perri, Giovanni Di;Bonora, Stefano
Last
2018-01-01

Abstract

Atazanavir/ritonavir concentrations change over pregnancy in HIV-positive patients; the impact of genetic variants is unknown. 20 patients were enrolled: antiretrovirals' plasma and intracellular concentrations were measured in addition to single nucleotide polymorphisms in transport affecting genes. Linear logistic regression showed that genetic variants in organic-anion-transporter-1B1 and pregnane-X-receptor encoding genes affected third trimester atazanavir exposure. In this prospective study genetic variants partially explained the observed inter-patient variability in third-trimester antiretrovirals' exposure.
2018
1
1
1
5
Focà, Emanuele; Calcagno, Andrea; Bonito, Andrea; Cusato, Jessica; Domenighini, Elisabetta; D'Avolio, Antonio; Roldan, Eugenia Quiros; Trentini, Laura; Castelnuovo, Filippo; Perri, Giovanni Di; Castelli, Francesco; Bonora, Stefano
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1678683
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