Indocyanine green was encapsulated inside the pores of pegylated amino-functionalized MCM-41 Mesoporous Silica Nanoparticles (ICG-MSNs). In addition to a greater stability and a decrease of toxicity, the photoacoustic effect of ICG-MSNs increases by nearly 400% compared to free ICG due to fluorescence quenching and high photothermal conversion of the encapsulated dyes. Upon i.v. administration in tumor-bearing mice, an overall photoacoustic enhancement of ca. 25% was measured in the tumor region.

Large photoacoustic effect enhancement for ICG confined inside MCM-41 mesoporous silica nanoparticles

Ferrauto G
First
;
Di Gregorio E;Aime S.
2017-01-01

Abstract

Indocyanine green was encapsulated inside the pores of pegylated amino-functionalized MCM-41 Mesoporous Silica Nanoparticles (ICG-MSNs). In addition to a greater stability and a decrease of toxicity, the photoacoustic effect of ICG-MSNs increases by nearly 400% compared to free ICG due to fluorescence quenching and high photothermal conversion of the encapsulated dyes. Upon i.v. administration in tumor-bearing mice, an overall photoacoustic enhancement of ca. 25% was measured in the tumor region.
2017
Inglese
Esperti anonimi
9
1
99
103
5
http://www.rsc.org/publishing/journals/NR/Index.asp
Materials Science (all)
no
1 – prodotto con file in versione Open Access (allegherò il file al passo 6 - Carica)
262
6
Ferrauto G, Carniato F, Di Gregorio E, Tei L, Botta M, Aime S.
info:eu-repo/semantics/article
none
03-CONTRIBUTO IN RIVISTA::03A-Articolo su Rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1678775
Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus 33
  • ???jsp.display-item.citation.isi??? 30
social impact