BACKGROUND There is limited information on gender differences in patients with Brugada syndrome (BrS) who experienced arrhythmic events (AEs). OBJECTIVE The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between males and females in patients with BrS with their first AE. METHODS The multicenter Survey on Arrhythmic Events in BRUgada Syndrome collected data on the first AE in 678 patients with BrS including 619 males (91.3%) and 59 females (8.7%) aged 0.27–84 years (mean age 42.5 6 14.1 years) at the time of AE occurrence. RESULTS After excluding pediatric patients, it was found that fe- males were older than males (49.5 6 14.4 years vs 43 6 12.7 years, respectively; P 5 .001). Higher proportions of females were observed in the pediatric and elderly populations. In Asians, the male to female ratio for AEs was 9-fold higher than that in White. Spontaneous type 1 BrS ECG was associated with an earlier onset of AEs in pediatric females. A similar prevalence (65%) of spontaneous type 1 BrS ECG was present in males and females above the age of 60 years. Females less frequently showed spontaneous type 1 BrS ECG (41% vs 69%; P < .001) or arrhythmia inducibility at electrophysiology study (36% vs 66%; P < .001). An SCN5A mutation was more frequently found in females (48% vs 28% in males; P = .007). CONCLUSION This study confirms that female patients with BrS are much rarer, display less type 1 Brugada ECG, and exhibit lower inducibility rates than do males. It shows for the first time that female patients with BrS with AE have higher SCN5A mutation rates as well as the relationship between gender vs age at the onset of AEs and ethnicity.

Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients

Giustetto, Carla;Gaita, Fiorenzo;
2018-01-01

Abstract

BACKGROUND There is limited information on gender differences in patients with Brugada syndrome (BrS) who experienced arrhythmic events (AEs). OBJECTIVE The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between males and females in patients with BrS with their first AE. METHODS The multicenter Survey on Arrhythmic Events in BRUgada Syndrome collected data on the first AE in 678 patients with BrS including 619 males (91.3%) and 59 females (8.7%) aged 0.27–84 years (mean age 42.5 6 14.1 years) at the time of AE occurrence. RESULTS After excluding pediatric patients, it was found that fe- males were older than males (49.5 6 14.4 years vs 43 6 12.7 years, respectively; P 5 .001). Higher proportions of females were observed in the pediatric and elderly populations. In Asians, the male to female ratio for AEs was 9-fold higher than that in White. Spontaneous type 1 BrS ECG was associated with an earlier onset of AEs in pediatric females. A similar prevalence (65%) of spontaneous type 1 BrS ECG was present in males and females above the age of 60 years. Females less frequently showed spontaneous type 1 BrS ECG (41% vs 69%; P < .001) or arrhythmia inducibility at electrophysiology study (36% vs 66%; P < .001). An SCN5A mutation was more frequently found in females (48% vs 28% in males; P = .007). CONCLUSION This study confirms that female patients with BrS are much rarer, display less type 1 Brugada ECG, and exhibit lower inducibility rates than do males. It shows for the first time that female patients with BrS with AE have higher SCN5A mutation rates as well as the relationship between gender vs age at the onset of AEs and ethnicity.
2018
15
10
1457
1465
http://www.elsevier.com/inca/publications/store/7/0/2/3/3/3/index.htt
Brugada ECG; Ethnicity; Implantable cardioverter-defibrillatorEthnicity; SCN5A mutation; Sudden cardiac death; Cardiology and Cardiovascular Medicine; Physiology (medical)
Milman, Anat; Gourraud, Jean-Baptiste; Andorin, Antoine; Postema, Pieter G.; Sacher, Frederic; Mabo, Philippe; Conte, Giulio; Giustetto, Carla; Sarquella-Brugada, Georgia; Hochstadt, Aviram; Kim, Sung-Hwan; Juang, Jimmy J.M.; Maeda, Shingo; Takahashi, Yoshihide; Kamakura, Tsukasa; Aiba, Takeshi; Leshem, Eran; Michowitz, Yoav; Rahkovich, Michael; Mizusawa, Yuka; Arbelo, Elena; Huang, Zhengrong; Denjoy, Isabelle; Wijeyeratne, Yanushi D.; Napolitano, Carlo; Brugada, Ramon; Casado-Arroyo, Ruben; Champagne, Jean; Calo, Leonardo; Tfelt-Hansen, Jacob; Priori, Silvia G.; Takagi, Masahiko; Veltmann, Christian; Delise, Pietro; Corrado, Domenico; Behr, Elijah R.; Gaita, Fiorenzo; Yan, Gan-Xin; Brugada, Josep; Leenhardt, Antoine; Wilde, Arthur A.M.; Brugada, Pedro; Kusano, Kengo F.; Hirao, Kenzo; Nam, Gi-Byoung; Probst, Vincent; Belhassen, Bernard*
File in questo prodotto:
File Dimensione Formato  
Gender Differences in Patients with Brugada Syndrome and Arrhythmic Events.doc

Accesso riservato

Descrizione: Articolo principale
Tipo di file: PREPRINT (PRIMA BOZZA)
Dimensione 222.5 kB
Formato Adobe PDF
222.5 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Gender Differences in Patients with Brugada Syndrome and Arrhythmic Events.pdf

Accesso aperto

Tipo di file: PREPRINT (PRIMA BOZZA)
Dimensione 242 kB
Formato Adobe PDF
242 kB Adobe PDF Visualizza/Apri
Milman et al. Gender differences in patients with Brugada syndrome and arrhythmic events Data from a survey on arrhythmic events in 678 patients - main.pdf

Accesso riservato

Tipo di file: PDF EDITORIALE
Dimensione 653.47 kB
Formato Adobe PDF
653.47 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1679528
Citazioni
  • ???jsp.display-item.citation.pmc??? 23
  • Scopus 60
  • ???jsp.display-item.citation.isi??? 56
social impact