Triple negative breast cancer (TNBC) easily develops resistance to the first-line drug doxorubicin, because of the high levels of the drug efflux transporter P-glycoprotein (Pgp) and the activation of pro-survival pathways dependent on endoplasmic reticulum (ER). Interfering with these mechanisms may overcome the resistance to doxorubicin, a still unmet need in TNBC.

Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer

Salaroglio, Iris C;Gazzano, Elena;Mungo, Eleonora;Castella, Barbara;ABDELRAHMAN, GAMALELDEIN FATHY ABDELLATEF;Massaia, Massimo;Donadelli, Massimo;Riganti, Chiara
Co-last
;
Kopecka, Joanna
Co-last
2018

Abstract

Triple negative breast cancer (TNBC) easily develops resistance to the first-line drug doxorubicin, because of the high levels of the drug efflux transporter P-glycoprotein (Pgp) and the activation of pro-survival pathways dependent on endoplasmic reticulum (ER). Interfering with these mechanisms may overcome the resistance to doxorubicin, a still unmet need in TNBC.
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CAAT/enhancer binding protein (C/EBP)-β; Calreticulin; Doxorubicin; Endoplasmic reticulum stress; P-glycoprotein; Triple negative breast cancer
Salaroglio, Iris C; Gazzano, Elena; Abdullrahman, Ahmad; Mungo, Eleonora; Castella, Barbara; Abd-Elrahman, Gamal Eldein Fathy Abd-Ellatef; Massaia, Massimo; Donadelli, Massimo; Rubinstein, Menachem; Riganti, Chiara; Kopecka, Joanna
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1683405
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